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KGF And FGFR2b Are Players In Cancer And Cancer Therapy

Keratinocyte growth factor (KGF) is used to limit epithelial tissue damage from radiation and chemotherapy in patients with blood cancers. However, concerns arise over whether KGF's use in patients with epithelial tumors could lead to tumor growth or protect the tumor cells from the killing effect of radiation and chemotherapy.

A review by Paul W. Finch, Ph.D., of Croton-on-Hudson in New York and Jeffrey S. Rubin, M.D., Ph.D., of the National Cancer Institute in Bethesda, Md., suggests KGF and its receptor (FGFR2b) typically do not stimulate the formation and growth of tumors. Rather, research suggests that in some situations expression of FGFR2b may induce cell death. The authors review KGF and FGFR2b's involvement in various cancers.

Highlights in the June 21 JNCI Contact: NCI Press Officers, 301-496-6641, NCIPressOfficers@mail.nih.gov

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Article adapted by Start Sanatate from original press release.
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Contact: Ariel Whitworth

Journal of the National Cancer Institute





KGF ªi FGFR2b Sunt jucãtori de cancer ºi de Cancer Terapie - KGF And FGFR2b Are Players In Cancer And Cancer Therapy - articole medicale engleza - startsanatate