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Minimally Invasive Technologies To Examine Endpoints In Phase I Trials

Increased use of minimally invasive technologies, such as positron emission tomography (PET) and magnetic resonance spectroscopy (MRS), may help scientists better understand how drugs in phase I clinical trials work in the body and interact with target cells, a review suggests. The authors propose that these technologies be developed further.

Currently, phase I clinical trials of new drugs often do not include basic information about how the drug works in the body. Based on several years experience with clinical trials in the UK, Paul Workman, Ph.D., of the Institute of Cancer Research in Sutton, and colleagues review a number of methods that could be used to examine how a drug is absorbed, metabolized, and eliminated by the body, as well as what it does to the body. The authors suggest that more money should be invested in developing minimally invasive technologies, to improve the speed and quality of drug development.

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Article adapted by Start Sanatate from original press release.
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Highlights from the May 2006 Journal of the National Cancer Institute

Contact: Nadia Ramsey, Institute of Cancer Research

Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jncicancerspectrum.oxfordjournals.org/.

Contact: Ariel Whitworth
Journal of the National Cancer Institute





Minim invazive Tehnologii pentru a examina obiective În Etapa I Procesele - Minimally Invasive Technologies To Examine Endpoints In Phase I Trials - articole medicale engleza - startsanatate