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Researchers Identify Activation Pathway For Two Proteins Involved In Cancer Cell Death

A new study by Chifumi Kitanaka, M.D., Ph.D., of the Yamaguta University School of Medicine in Japan, and colleagues shows that two molecules called Bax and Bak, which are integral to a type of cell death, depend on oxidative phosphorylation, for their activity. Oxidative phosphorylation is the process by which mitochondria in the cell create useable energy. Tumor cells often produce energy through glycolysis, a type of glucose breakdown, rather than oxidative phosphorylation. Therefore, they can be resistant to programmed cell death under stressful conditions. The authors' findings could have therapeutic implications in that tumor cells might be treated to make them more susceptible to programmed cell death.

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Article adapted by Start Sanatate from original press release.
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Other highlights in the October 18 JNCI

Contact: Chifumi Kitanaka

Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jncicancerspectrum.oxfordjournals.org/.

Contact: Ariel Whitworth
Journal of the National Cancer Institute





Cercetatori Identificaþi Activation cale pentru douã proteine implicate în moartea celulelor de Cancer - Researchers Identify Activation Pathway For Two Proteins Involved In Cancer Cell Death - articole medicale engleza - startsanatate