ANALIZE MEDICALE DE LABORATOR
Aici gasiti analizele medicale grupate pe categorii precum si detalii generale si specifice pentru categoriile respective.
Selectati o categorie din lista de mai jos:
Solutie antistress!
Construieste poduri :)
Prinde pisica neagra :)
20 Years of Fainting Spells - Researchers in Berlin Discover Cause for Severe Neurological Disorder - First Hope for Effective Therapy
As soon as the 43-year-old patient stood upright, his blood pressure
dropped from 140 to 50 mm on the mercury column within a few
seconds. Over the last 20 years, he had had recurrent fainting spells
with loss of consciousness.
He also reported decreased sweating, dry
mouth, dry eyes, distended abdomen, and problems with digestion. His
colon was so dilated that his liver had shifted from the right to the left
side of his abdomen and his stomach was squeezed between his liver
and spleen.
He could hardly eat or drink anything anymore and was so
emaciated that he was afraid he would slowly starve to death. Now, Dr.
Christoph Schröder, Professor Friedrich Luft, and Professor Jens
Jordan from the Clinical Research Center of the Franz Volhard Clinic
(Charité and Helios Clinics Berlin Buch and the Max Delbrück Center
for Molecular Medicine, MDC, Berlin-Buch) have shown that an
autoantibody that blocks ganglionic receptors of the autonomous
(vegetative) nervous system causes the grave and rare disease.
The
autonomic nervous system regulates vital processes such as
heartbeat, blood pressure, blood glucose level, metabolism, lung and
bladder function, and digestion.
On four consecutive days, they
replaced the blood plasma of the patient with donor plasma and thus
washed the antibodies out of the blood. At the same time, he received
medications (prednisolone and azathioprine) to suppress antibody
formation.
As a result, the patient's health condition and quality of life
improved dramatically and he was able to resume his work. One year
after the treatment, his condition remains stable. "For the first time,
there is hope for an effective treatment for these patients", Professor
Jordan explained. The paper has now been published in the New
England Journal of Medicine (NEJM)* (Vol. 353, Nr. 15, pp. 1585-1590,
October 13, 2005).
The autoantibodies work like ganglionic blockers - drugs that used to
be prescribed to treat severe hypertension. Both the patient's
autoantibodies and ganglionic blockers occupy the binding site
(receptor) for acetylcholine.
The neurotransmitter acetylcholine is
required for the transmission of sympathetic and parasympathetic
nervous system activity. Both branches of the autonomic nervous
system balance organ functions. By removing the antibodies and
suppressing their new formation through drugs, the clinicians proved
that it was in fact the autoantibodies which caused the patient's severe
neurological disorder. Why the patient's body forms these antibodies,
however, is unknown.
Professor Jordan, who also heads a research
group on disorders of the autonomic nervous system at the MDC, and
his colleagues point out that patients with severe blood pressure drops
while standing up and additional disorders of the autonomic nervous
system should be tested for antibodies against ganglionic acetylcholine
receptors.
* Plasma Exchange for Primary Autoimmune Autonomic Failure
Christoph Schroeder, Steven Vernino, Andreas L. Birkenfeld, Jens
Tank, Karsten Heusser, Axel Lipp, Thomas Benter, Carsten
Lindschau, Ralph Kettritz, Friedrich C. Luft and Jens Jordan
From the Franz Volhard Clinical Research Center and the Max
Delbrück Center for Molecukar Medicine (C.S., A.L.B., J.T., K.H., C.L.,
R.K., F.C.L., J.J.) , Medical University Charité (C.S., A.L.B., J.T., K.H.,
C.L., R.K., F.C.L., J.J) and Helios Klinikum (T.B.) - all in Berlin; and the
Department of Neurology, University of Texas Southwestern Medical
Center, Dallas (S.V.).
Press Office
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Barbara Bachtler
Robert-Rössle-Straße 10
13125 Berlin
Germany
Phone: 0049/30/94 06 - 38 96
Fax: 0049/30/94 06 - 38 33
presse@mdc-berlin.de
mdc-berlin.de
20 de ani de Fainting vrãji - Cercetatori de la Berlin Descoperiti ca pentru tulburãri neurologice severe - Prima de speranta pentru efectivã Terapie - 20 Years of Fainting Spells - Researchers in Berlin Discover Cause for Severe Neurological Disorder - First Hope for Effective Therapy - articole medicale engleza - startsanatate