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A New Approach To Study Flu Drug Resistance
Researchers have created a new approach for studying resistance to
Neuraminidase Inhibitors (NI) in influenza. The study, published December
7 in PLoS
Computational Biology, combines data from influenza infections of human
volunteers with a mathematical model which estimates the expected number
of
newly generated resistant infections. This new approach provides a more
meaningful assessment of the danger of drug resistance emergence, compared
to
the current way of reporting the fraction/number of resistant cases.
Neuraminidase Inhibitors are currently the most effective drugs against
influenza. However, recent cases of resistance to NI have caused some
concern. A number of studies have reported that resistant mutants could
be isolated from a fraction of patients treated with Neuraminidase
Inhibitors. While this provides some qualitative insights, it is even more
important to know how likely an infected, treated patient will generate
resistance to NI and will cause infections with the resistant strain in
others.
A team from Emory University, the Fred Hutchinson Cancer Research Center,
and the University of Washington set out to determine this likelihood.
Since
the epidemiological data that is customarily used to estimate parameters
of this type is not available for NI resistant influenza, the team, led by
Dr. Andreas Handel, used an alternative approach. The team took data from
volunteers infected with the flu and combined it with a mathematical
framework to obtain a more quantitative assessment of the danger of
resistance.
This result could predict models of resistance emergence and spread. The
study additionally shows that the results depend strongly on the role the
immune response plays; this is an issue that will be important to address
in future studies.
CITATION: Handel A, Longini IM Jr, Antia R (2007) Neuraminidase inhibitor
resistance in influenza: Assessing the danger of its generation and
spread.
PLoS Comput Biol 3(12): e240. doi:10.1371/journal.pcbi.0030240
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O nouã abordare a consumului de droguri de rezistenþã Studiul Gripã - A New Approach To Study Flu Drug Resistance - articole medicale engleza - startsanatate