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Aung FootHealth Clinics & Advanced Wound Care Center Enrolling Patients With Chronic Diabetic Foot Ulcers For Matrix Clinical Trial
Aung FootHealth Clinics &
Advanced Wound Care Center announced it is recruiting patients with
lower extremity diabetic foot ulcers to participate in the MATRIX clinical
trial. The MATRIX trial will study the effects of Excellarate(TM) (GAM501)
(Ad5PDGF-B/bovine Type I collagen gel) for the potential treatment of
patients with neuropathic non-healing diabetic foot ulcers. Excellarate is
an investigational product designed to stimulate the process of wound
healing.
The MATRIX (A Phase 2b Study of GAM501 in the Treatment of Diabetic
Ulcers in the Lower Extremities) trial is a randomized, double-blind,
placebo-controlled, comparator arm (standard of care) safety and efficacy
study to evaluate GAM501 (Ad5PDGF-B/bovine type I collagen gel) that is
topically administered once or twice over the course of the study. The
primary endpoint will be the effect of Excellarate on the incidence of
complete ulcer closure at 12 weeks or earlier.
"The Excellarate topical gel using Gene Activated Matrix (GAM)
technology is designed to provide localized and sustained cellular release
of platelet-derived growth factor-BB protein (PDGF-BB). Sustained delivery
of PDGF-BB directly at the wound site is believed to stimulate angiogenesis
and granulation tissue formation through the recruitment and proliferation
of chemotactic cells such as monocytes, fibroblasts, and endothelial cells,
which are necessary for the stimulation of a variety of wound healing
processes," stated Barbara J. Aung, DPM, CWS Aung FootHealth Clinics &
Advanced Wound Care Center, and a trial investigator.
There are currently more than 20 million Americans who have diabetes
and this number is expected to double by the year 2030. Many diabetic
patients suffer from peripheral neuropathy, or a loss of feeling in their
feet, that puts them at increased risk of foot ulceration. Over 850,000
chronic diabetic ulcers are diagnosed in the U.S. each year. Patients with
non-healing ulcers are more susceptible to infections that may lead to
amputation of the affected foot or leg.
Aung FootHealth Clinics & Advanced Wound Care Center is among an
estimated 25 sites participating in the MATRIX trial. The trial is expected
to enroll 210 patients nationwide.
For over 15 years Barbara J. Aung, DPM, CWS and Aung FootHealth Clinics
& Advanced Wound Care Center has been a leader in the field of Podiatric
Medicine specializing in Advanced Wound Care, Limb Preservation and
Amputation Prevention. Most chronic/long standing wounds that are treated
in our wound care center heal within 8-12 weeks. In fact, over 95% of the
wounds that are treated heal fully. Using proven clinical pathways, our
specifically trained staff provides comprehensive individualized treatment
to patients.
Please visit our website at http://www.healthy-feet.com for additional
information on "Keeping your Feet Healthy for the Journeys...Yet to be
Made."
Aung FootHealth Clinics & Advanced Wound Care Center
http://www.healthy-feet.com
Aung FootHealth & Clinici avansat centru de îngrijire a plãgilor, unde se pregãtesc pacienþii cu ulcere cronice piciorului diabetic pentru matrice studiu clinic - Aung FootHealth Clinics & Advanced Wound Care Center Enrolling Patients With Chronic Diabetic Foot Ulcers For Matrix Clinical Trial - articole medicale engleza - startsanatate