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BioLineRx Announces Positive Results From Phase 2a Trial Of BL-1020, A GABA-Enhanced Antipsychotic For The Treatment Of Schizophrenia

BioLineRx Ltd. (TASE:BLRX), a clinical stage drug development company, announced positive results from a Phase 2a trial of BL-1020, a GABA-enhanced antipsychotic. BL-1020 showed statistically significant efficacy with no significant change in weight and no increase in extrapyramidal symptoms at study completion. The Company had announced positive interim results from the trial in October 2007.

The trial was an open label, 6-week study conducted under Good Clinical Practices guidelines designed to determine the safety and maximum tolerated dose of BL-1020 in schizophrenic patients. The study was conducted on 36 treatment refractory hospitalized patients of whom only 3 withdrew early from the study. Patients were started on 32mg (20mg free base) of BL-1020 and received increasing dosages over the first 7 days in order to reach the maximum dose of 64 mg (40mg free base). Significant improvement was seen already after 7 days of treatment.

The results of the study were as follows:

- Patients being treated with BL-1020 experienced a statistically significant improvement from baseline in the Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression of Severity and Improvement (CGI-S; CGI-I), which are widely recognized measures of severity and improvement in schizophrenia. There was a statistically significant (p





BioLineRx anunþã rezultate pozitive de la faza 2a proces de BL-1020, A GABA-consolidatã de antipsihotice pentru tratamentul schizofreniei - BioLineRx Announces Positive Results From Phase 2a Trial Of BL-1020, A GABA-Enhanced Antipsychotic For The Treatment Of Schizophrenia - articole medicale engleza - startsanatate