ANALIZE MEDICALE DE LABORATOR
Aici gasiti analizele medicale grupate pe categorii precum si detalii generale si specifice pentru categoriile respective.
Selectati o categorie din lista de mai jos:
Solutie antistress!
Construieste poduri :)
Prinde pisica neagra :)
Blocking Aggrecanase-2 Activity Prevents Cartilage Erosion In Arthritis
The protein aggrecan comprises up to 10% of the dry weight of the cartilage in our joints, and aggrecan breakdown by enzymes known as aggrecanases occurs in arthritis. Aggrecanases cleave aggrecan at two sites within the protein - at a site within the CS-2 domain and at a second site in the interglobular domain (IGD). Recently, the enzyme aggrecanase-2 was identified as the predominant aggrecanase in mouse cartilage, however researchers were unable to distinguish aggrecanase-2 activity at the CS-2 domain from that at the IGD. In order to assess the contribution of this specific cleavage to cartilage destruction, Amanda Fosang and colleagues from the University of Melbourne created mice with a mutation that made the IGD resistant to aggrecanase. They found that blocking cleavage in the IGD diminished the loss of aggrecan and cartilage erosion in animals with osteoarthritis and inflammatory arthritis. In addition, this blockade appeared to stimulate cartilage repair following acute inflammation. The authors concluded that blocking aggrecanase-mediated cleavage in the aggrecan IGD alone was sufficient to protect against cartilage erosion in arthritis and may contribute to cartilage repair. The study appears online in advance of publication in the June print issue of the Journal of Clinical Investigation.
TITLE: Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair
AUTHOR CONTACT:
Amanda J. Fosang
University of Melbourne and Murdoch Children's Research Institute, Parkville, Victoria, Australia.
----------------------------
Article adapted by Start Sanatate from original press release.
----------------------------
JCI table of contents -- May 17, 2007
Contact: Brooke Grindlinger
Journal of Clinical Investigation
De blocare Aggrecanase-2 activitate previne eroziunea cartilajului în artrita - Blocking Aggrecanase-2 Activity Prevents Cartilage Erosion In Arthritis - articole medicale engleza - startsanatate
