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Bone Mineral Content Continues To Increase In Obese Adolescents During Weight Loss
Obese teenagers who
succeeded in losing weight in a year-long medically supervised weight
control program also saw their bone mineral content increase over that
period, say researchers from The Children's Hospital of Philadelphia. The
finding was reassuring, because adolescence is a critical period for bone
health in later life.
A study in the current issue of the journal Obesity studied 62
adolescents between the ages of nine and 17 years who participated in a
trial looking at the effectiveness of a comprehensive, family-based,
behavioral weight control program in conjunction with a weight loss drug,
sibutramine. The researchers previously reported the combination of
behavioral changes and medication helped very obese teenagers lose weight.
In adults, obesity is associated with increased bone mineral density
and voluntary weight loss is associated with a decrease in bone mineral
density. The findings in this study show that bone mineral content
continues to increase in this adolescent population despite weight loss.
"The growing pediatric obesity epidemic raises important clinical and
public health questions about the effects on lifelong bone health of early
onset obesity and its treatment," said Nicolas Stettler, M.D., M.S.C.E.,
pediatric nutrition specialist at The Children's Hospital of Philadelphia
and lead author of this study. "Although fractures due to low bone mineral
content are mainly a problem for the elderly, the amount of bone mass
acquired during puberty is the key determinant of lifetime fracture risk."
Using a dual energy X-ray absorptiometry scanner (DXA), researchers
looked at specific body areas including legs, arms and lumbar spine as well
as the bone mineral content of the whole body. The data was compared with a
reference group of 66 adolescents. Bone mineral content of the obese
subjects was higher than that of the reference group at the beginning and
end of the study.
When looking at each subject's bone mineral content, adjusted for their
height, the researchers noticed that bone mineral content in the arms and
legs increased less than would be expected with growth while the lumbar
spine content increased more than expected. These changes in bone mineral
content were largely explained by changes in the amount of fat and muscle
in the body during the intensive weight loss program.
"As obesity treatment during adolescence becomes more frequent, it is
important to understand the role of weight loss on bone health during this
critical period," Dr. Stettler added.
This study was supported by the National Institutes of Health, the
General Clinical Research Center at Children's Hospital, Knoll
Pharmaceutical and Abbott Laboratories.
Dr. Stettler's coauthors were: Robert I. Berkowitz, M.D., chief of
child and adolescent psychiatry at Children's Hospital; Joanna Cronquist of
Children's Hospital; Justine Shults of the Center for Clinical Epidemiology
and Biostatistics, University of Pennsylvania School of Medicine; Thomas A.
Wadden, of the Weight and Eating Disorders Program at the University of
Pennsylvania School of Medicine; and Babette S. Zemel, Ph.D.; and Mary B.
Leonard, M.D. both of Children's Hospital.
About The Children's Hospital of Philadelphia: The Children's Hospital
of Philadelphia was founded in 1855 as the nation's first pediatric
hospital. Through its long-standing commitment to providing exceptional
patient care, training new generations of pediatric healthcare
professionals and pioneering major research initiatives, Children's
Hospital has fostered many discoveries that have benefited children
worldwide. Its pediatric research program is among the largest in the
country, ranking third in National Institutes of Health funding. In
addition, its unique family-centered care and public service programs have
brought the 430-bed hospital recognition as a leading advocate for children
and adolescents. For more information, visit http://www.chop.edu.
The Children's Hospital of Philadelphia
http://www.chop.edu
Minerale osoase conþinut continuã sã creascã în adolescenþi obezi pierdere în greutate în timpul - Bone Mineral Content Continues To Increase In Obese Adolescents During Weight Loss - articole medicale engleza - startsanatate