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Cleveland Clinic To Lead First Head-to-Head Comparison Of The Two Most Potent Statins
Cleveland Clinic researchers will
coordinate the first head-to-head comparison of the two most powerful
statin medications. The trial intends to begin enrollment as early as next
week. Statins are the world's most commonly prescribed drugs and widely
used to treat patients with elevated cholesterol levels.
The two drugs, atorvastatin (Lipitor) and rosuvastatin (Crestor), lower
LDL ("bad") cholesterol and raise HDL ("good") cholesterol. But which drug
is best for patients with heart disease? This study will seek to answer
this important scientific question by measuring the rate of regression of
coronary disease using intravascular ultrasound (IVUS), a technique that
directly measures the amount of plaque in the coronary arteries.
The SATURN study (Study of Coronary Atheroma by InTravascular
Ultrasound: Effect of Rosuvastatin Versus AtorvastatiN) will compare the
ability of these two statins to stop the progression of atherosclerosis,
the main cause of cardiovascular disease, over a two year treatment period.
SATURN, a multicenter, double-blind Phase IIIb trial, will use IVUS
imaging to study approximately 1,300 patients at 150 hospitals in 20
countries worldwide. The trial is expected to be completed in 2011.
Cleveland Clinic cardiologist Stephen J. Nicholls, M.D., PhD., will lead
the trial.
Cleveland Clinic researchers have conducted two previous studies with
IVUS looking at statins and the rate of atherosclerosis regression.
Researchers have found a significant benefit with statins by intensively
lowering LDL- cholesterol and the inflammatory marker C-reactive protein
(CRP) and by raising levels of HDL cholesterol. SATURN aims to determine if
differences in the ability of the different statins to lower LDL and raise
HDL can promote regression (reduction in the amount of plaque in the
coronary arteries).
About Cleveland Clinic
Cleveland Clinic, located in Cleveland, Ohio, is a not-for-profit
multispecialty academic medical center that integrates clinical and
hospital care with research and education. Cleveland Clinic was founded in
1921 by four renowned physicians with a vision of providing outstanding
patient care based upon the principles of cooperation, compassion and
innovation. U.S. News & World Report consistently names Cleveland Clinic as
one of the nation's best hospitals in its annual "America's Best Hospitals"
survey. Approximately 1,800 full-time salaried physicians and researchers
at Cleveland Clinic and Cleveland Clinic Florida represent more than 100
medical specialties and subspecialties. In 2006, there were 3.1 million
outpatient visits to Cleveland Clinic. Patients came for treatment from
every state and from more than 80 countries. There were more than 53,000
hospital admissions to Cleveland Clinic in 2006. Cleveland Clinic's Web
site address is http://www.clevelandclinic.org.
Cleveland Clinic
http://www.clevelandclinic.org
Cleveland Clinic de a conduce Prima Head-to-ºef comparaþie a douã dintre cele mai potent Statins - Cleveland Clinic To Lead First Head-to-Head Comparison Of The Two Most Potent Statins - articole medicale engleza - startsanatate