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Consuming Alcohol May Lead To High Blood Pressure
People who drink regularly have higher systolic blood pressure than
people who do not, according to a recent article published in PLoS
Medicine. Researcher Sarah Lewis (University of
Bristol, UK) and colleagues report that systolic blood
pressure levels are about 7 mmHg higher in frequent drinkers than in
people who do not drink.
Systolic blood pressure refers to the peak pressure in the arteries
around the time that the heart muscle contracts. It is measured in
millimeters of mercury (mmHg), and a normal value for a resting,
healthy adult human is 120 mmHg.
The study authors conducted a meta-analysis by assessing results from
five published studies. Each study focused on the link between blood
pressure and a variation in the gene for aldehyde dehydrogenase 2
(ALDH2) - the enzyme that removes alcohol from the body.
Some individuals receive two copies of the variant form of this gene
from their parents. They have the ALDH2 *2*2 genotype and experience
adverse symptoms when drinking alcohol such as nausea and flushness.
Other people receive a *1*2 genotype or a *1*1 genotype and
consequently drink more alcohol than those with the *2*2 genotype.
Since alcohol consumption seems to be the only lifestyle factor that
the genetic variants affect, the authors argue that a relationship
between ALDH2 genotypes and blood pressure is sufficient to establish a
relationship between blood pressure and alcohol intake.
The ALDH2 gene variant is common in Japan, and most of the studies in
the analysis were performed there. To aid interpretation of the
results, the three genotypes can be grouped according to degree of
alcohol intake:
*1*1 genotype has highest alcohol intake
*1*2 genotype has intermediate alcohol intake
*2*2 genotype has lowest alcohol intake
Those with the *1*1 variant were 2.42 more likely to have hypertension
than those with the *2*2 variant. People with the *1*2 variant were
1.72 times more likely to have hypertension than those with the *2*2
genotype. The researchers found no link between ALDH2 and
hypertension among the women subgroup because they drank very little on
average.
Narrowly, the findings suggest that for Japanese men, the degree of
alcohol consumption has an effect on blood pressure. In order to expand
results and improve the estimate of alcohol's effect on blood pressure,
additional large-scale studies are necessary.
Alcohol and blood pressure: A systematic review implementing a
mendelian randomization approach.
Chen L, Davey Smith G, Harbord R, and Lewis SJ
PLoS Medicine (2008). 5(3): e52.
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About PLoS Medicine
PLoS Medicine is an open access, freely available international medical
journal. It publishes original research that enhances our understanding
of human health and disease, together with commentary and analysis of
important global health issues. For more information, visit http://www.plosmedicine.org
About the Public Library of Science
The Public Library of Science (PLoS) is a non-profit organization
of scientists and physicians committed to making the world's
scientific and medical literature a freely available public resource.
For more information, visit http://www.plos.org
Written by: Peter M Crosta
Copyright: Start Sanatate
Not to be reproduced without permission of Start Sanatate
Consumatoare de alcool poate duce la hipertensiune arterialã - Consuming Alcohol May Lead To High Blood Pressure - articole medicale engleza - startsanatate