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ESOMEPRAZOLE offers at-risk patients effective protection from nsaid associated ulcers

Data released today demonstrates that esomeprazole (NexiumÒ) is the first proton pump inhibitor (PPI) shown to be effective in the prevention of gastric and duodenal ulcers (GU/DU) associated with the use of all non-steroidal anti-inflammatory drugs (NSAIDs), including cyclo-oxygenase-2- (COX-2) selective NSAIDs.1,2 NexiumÒ has also been shown to be effective in healing GU.1,2

All NSAIDs carry a risk of upper gastrointestinal (GI) side-effects - it has been estimated that 15-25 per cent of NSAID users experience upper GI symptoms3,4,5 and as many as 10-30 per cent of long-term NSAID users develop GU or DU.6 In the UK, NSAIDs cause approximately 3,500 hospitalisations for, and 400 deaths from, ulcer bleeding per annum in those aged 60 years and above.7

The results of a major new pan-European patient survey by the PARE (People with Arthritis / Rheumatism in Europe) Manifesto Steering Group also showed that 35 per cent of people with arthritis / rheumatism experience NSAID-associated upper GI symptoms.8

Professor Neville Yeomans, University of Melbourne, Australia, lead author of one of the studies presented at the European League Against Rheumatism (EULAR) congress, said that effective therapy to treat NSAID-associated upper GI side-effects would help ease the burden to both patients and healthcare professionals.

"NSAID-associated upper GI side-effects, especially ulcers, are a significant problem and not only impair quality of life, but can also result in life-threatening complications, such as bleeding and perforation, and if you prevent ulcers you will prevent the possible complication of ulcers as well," he said.

Effective control of gastric acid secretion is a key factor in the management of NSAID-associated upper GI side-effects. NexiumÒ provides more effective acid control than all other PPIs,9 which in head-to-head comparative trials in gastroesophageal reflux disease (GERD), translates into greater clinical efficacy in the management of GERD.

Prevention of ulcers with Nexium®

In two randomised, controlled, multicentre trials, NexiumÒ significantly reduced the incidence of GU/DU compared with placebo in long-term NSAID users (n = 1,429). Around 95 per cent of patients on NexiumÒ 20 mg (94.8 per cent, p





ESOMEPRAZOLE oferte de la pacienþii cu risc de la o protecþie eficientã de AINS asociate ulcere - ESOMEPRAZOLE offers at-risk patients effective protection from nsaid associated ulcers - articole medicale engleza - startsanatate