Early Reports of Thrombosis after Insertion of Drug-Eluting Stents
More than 1•5 million people a year have stents implanted to improve coronary artery blood flow. A recently published pooled analysis of 11 trials (see Lancet 2004; 364: 583-91) suggested that DES-increasingly used in coronary angioplasty-have benefits over bare-metal stents (BMS) by reducing the need for later revascularisation and reducing the risk of cardiac events.
Patrick W Serruys (Erasmus Medical Center, Netherlands) and colleagues report four cases of angiographically-confirmed stent thrombosis that occurred around a year after elective implantation of polymer-based paxlitaxel-eluting or sirolimus-eluting stents; all four cases resulted in myocardial infarction (heart attack). All cases arose soon after antiplatelet therapy was interrupted.
Professor Serruys comments: "We report these cases to draw attention to a problem, with serious clinical implications, that might be under-reported. We suggest that the potential risk of stent occlusion should be considered when discontinuation of antiplatelet therapy is contemplated in patients with drugeluting stents.
As the use of drug-eluting stents becomes widespread, careful long-term follow-up of patients with such stents is needed to assess the true rate of late thrombosis."
In an accompanying commentary (p 1466), Mark J Eisenberg (Jewish General Hospital/McGill University, Montreal, Canada) concludes: "…drug-eluting stents are so new that many health-care professionals are not aware of the critical need for prolonged and continuous antiplatelet therapy. Therefore, both patients and physicians should be sensitised to the possibility of late stent-thrombosis if antiplatelet therapy is interrupted. The case reports by McFadden and colleagues strongly and persuasively suggest that stent thrombosis might occur many months after the implantation of a drug-eluting stent if prolonged and continuous antiplatelet therapy is not maintained."
Contact: Professor Patrick W Serruys, Department of Interventional Cardiology, Erasmus Medical Center, Thoraxcenter Room Bd 408, Dr Molewaterplein 40, 3015 GD, Rotterdam, Netherlands; T)+31 10 463 5260; p.w.j.c.serruys@erasmusmc.nl
(alternative contact) Dr Andrew Ong +31 10 4635 029; ao8888@yahoo.com.au
Dr Mark J Eisenberg, Division of Cardiology & Clinical Epidemiology, Jewish General Hospital Suite A-118, 3755 Cote St Catherine Road, Montreal, Quebec H3T 1E2, Canada; T)+1 514 340 8222 x 3564; marke@epid.jgh.mcgill.ca
http://www.thelancet.com
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