Eph affects T cell function
In the December 15 issue of the Journal of Clinical Investigation, Jiangping Wu and colleagues from Notre Dame Hospital, Montreal, now delve further into the role of Eph kinases in the immune system by showing that EphB6 modulates immune function.
The authors demonstrated that mice genetically deficient for EphB6 have compromised T cell responses. On the other hand, immune responses mediated by antibodies were normal in the mutant mice.
This study is the first to describe roles for an Eph kinase in in vivo immunological function and the data suggest that EphB6 is important for T cell-T cell cooperation during T cell activation.
TITLE: EphB6-null mutation results in compromised T cell function
AUTHOR CONTACT:
Jiangping Wu
Laboratory of Immunology, Notre Dame Hospital, Montreal, Quebec, Canada.
Phone: 514-890-8000 ext. 25164; Fax: 514-412-7596; E-mail: jianping.wu@umontreal.ca.
View the PDF of this article at: https://www.the-jci.org/press/21846.pdf
From 5:00PM USA EST Wednesday December 15, 2004 a PDF of this article will be available at:
http://www.jci.org/cgi/content/full/114/12/1762
Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
Eph afecteazã funcþia de celule T - Eph affects T cell function - articole medicale engleza - startsanatate