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Folate Deficiency Is Associated With A Three-Fold Increased Risk Of Dementia
Among elderly people, lower levels of folate can be associated with a
three-fold increase in risk for dementia, claims a study published in
the Journal of Neurology, Neurosurgery, and Psychiatry,
part of the British Medical Journal Specialist Journals, on February 5,
2008.
Folate, vitamin B12, and the protein homocysteine are involved in
reactions that are needed to produce several chemicals, including some
neurotransmitters, lipids, and nucleotides. Previously, studies have
shown a link between deficiencies in these chemicals and the prevalence
of dementia, however, the results have been controversial because of
the physical changes dementia often creates. High levels of
homocysteine have also been associated with cardiovascular disease.
In this study, the researchers followed 518 people over 2 years
(2001-2003), tracking the development of dementia within the
population. All participants were more than 65 years old and lived in
one rural or one urban area in the south of the country. To do this, at
the beginning and the end of the two year period, validated tests were
run to test for any dementing illness. Additionally, blood tests were
taken to assess folate, vitamin B12
Similarly,
blood tests were taken to assess levels of folate, vitamin B12, and
homocysteine levels, and the changes with time were observed. At the
beginning of the period, almost one in five participants showed high
levels of homocysteine, almost the same had low levels of vitamin B12,
and 3.5% were deficient in folate. Higher levels of folate were
associated with higher vitamin B12 levels and lower homocysteine.
At the end of the study, 45 of the participants had developed dementia.
Of these, 34 had been diagnosed with Alzheimer's disease, seven with
vascular dementia, and four with "other" types of dementia. Dementia
showed more prevalence in older patients, in the relatively uneducated,
the inactive, and those with deposits of the protein ApoE.
Dementia onset was more likely in those who were older, relatively
poorly educated, inactive, and had deposits of ApoE, a protein
associated with the breakdown of lipids. It was also much more likely
in those whose folate levels fell further over the two years while
homocysteine levels increased. Individuals with folate deficiency at
the start of the study were at risk for dementia almost 3.5 times more
than others.
This suggests, according to the authors, that changes in micronutrients
such as folate could be linked with the other typical signs that lead
up to dementia, such as weight loss and low blood pressure. Weight loss
could indicate a dietary change in quality or quantity of food intake,
but it is unlikely to itself change the levels of micronutrients in the
blood.
Changes in folate, vitamin B12 and homocysteine associated
with incident dementia
J-M Kim, R Stewart, S-W Kim, I-S Shin, S-J Yang, H-Y Shin, J-S Yoon
Journal of Neurology, Neurosurgery, and Psychiatry
2008
doi 10.1136/jnnp.2007.131482
Click
Here For Abstract
Written by Anna Sophia McKenney
Copyright: Start Sanatate
Not to be reproduced without permission of Start Sanatate
Folate este asociatã cu un deficit de trei ori Un risc crescut de demenþã - Folate Deficiency Is Associated With A Three-Fold Increased Risk Of Dementia - articole medicale engleza - startsanatate