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High Blood Pressure May Heighten Effects Of Alzheimer's Disease
Having hypertension, or high blood
pressure, reduces blood flow in the brains of adults with Alzheimer's
disease, according to a new study presented at the annual meeting of
the Radiological Society of North America (RSNA).
"While hypertension is not a cause of Alzheimer's disease, our study
shows that it is another hit on the brain that increases its vulnerability
to the effects of the disease," said study co-author Cyrus Raji, scientist
and M.D. and Ph.D. candidate at the University of Pittsburgh where the
study was conducted.
Hypertension is a condition in which the blood circulates through the
arteries with too much force. According to the National Heart, Lung and
Blood Institute, approximately 50 million Americans have hypertension.
People with hypertension are at elevated risk for heart attack, stroke and
aneurysm. Recently, there has been mounting evidence tying cardiovascular
health to brain health.
"This study demonstrates that good vascular health is also good for the
brain," said co-author Oscar Lopez, M.D., professor of neurology and
psychiatry at the University of Pittsburgh. "Even in people with
Alzheimer's disease, it is important to detect and aggressively treat
hypertension and also to focus on disease prevention."
For the study, the researchers used arterial spin-labeled magnetic
resonance imaging (MRI), which can measure blood flow in the brain, to
image 68 older adults. Arterial spin-labeled MRI is a novel, noninvasive
technique that requires no external contrast agent.
The patient group included 48 normal individuals, including 38 with
hypertension and 10 without; 20 Alzheimer's patients, including 10 with
hypertension and 10 without; and 20 adults with mild cognitive impairment,
10 with hypertension and 10 without. Mild cognitive impairment, which
affects brain functions such as language, attention and reasoning, is a
transition stage between normal aging deficits in the brain and greater
levels of dementia.
The MRI results showed that in all patient groups blood flow in the
brain was substantially decreased in patients with hypertension compared to
those without. Cerebral blood flow was lowest among the Alzheimer's
patients with hypertension, but the normal group with hypertension showed
significantly lower cerebral blood flow than the normal group without
hypertension.
"These results suggest that by changing blood flow to the brain,
hypertension -- treated or untreated -- may contribute to the pathology of
Alzheimer's," Raji said.
Co-authors are C. Lee, M.D., W. Dai, Ph.D., J.Becker, Ph.D., L. Kuller,
M.D., H. Gach, Ph.D., et al.
AT A GLANCE
-- Hypertension reduces cerebral blood flow in people with Alzheimer's
disease.
-- Arterial spin-labeled MRI is a novel, noninvasive imaging technique
that can measure cerebral blood flow.
-- Approximately 50 million Americans have hypertension.
RSNA is an association of more than 41,000 radiologists, radiation
oncologists, medical physicists and related scientists committed to
excellence in patient care through education and research. The Society is
based in Oak Brook, Ill. (RSNA.org)
Radiological Society of North America
http://www.rsna.org
Hipertensiunii arteriale mai spori Efectele bolii Alzheimer - High Blood Pressure May Heighten Effects Of Alzheimer's Disease - articole medicale engleza - startsanatate