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In Vitro Whole-Genome Analysis Identifies A Susceptibility Locus For HIV-1
Individuals differ in their susceptibility to the HIV-1 virus and the determinants of susceptibility are encoded in the human genome. Genetic variants
influencing this trait have been identified by investigating candidate genes thought likely to be involved in HIV-1 pathogenesis or by whole genome
association studies, which type more than 500,000 genetic variants per individual (genome-wide association studies) to see which ones associate with
susceptibility.
This week in the online open-access journal PLoS Biology, Corinne Loeuillet, Stylianos Antonarakis, and Amalio Telenti show how they
have addressed the issue of identification of new genetic variants influencing susceptibility to HIV-1 by a novel strategy based on the in vitro
infection of cells.
For this, immortalized B lymphocytes from 15 families (198 cell lines) were infected by a HIV-based vector. Differences in
cellular susceptibility to infection-a genetic trait-could be mapped to a precise region on chromosome 8, suggesting a role of the LY6 family of
GPI-anchored proteins in HIV-1 infection.
Genetic analysis of in vitro standardized cellular phenotypes provides a new approach to the discovery of
the basis of genetic susceptibility to infectious agents.
In vitro whole-genome analysis identifies a susceptibility locus for HIV-1
Loeuillet C, Deutsch S, Ciuffi A, Robyr D, Taffe´ P, et al.
PLoS Biol 6(2): e32. doi:10.1371/journal.pbio.0060032
Please click here to view article online
Plos Biology
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USA
In vitro-întreg genomul identificã o analizã de sensibilitate pentru loc geometric al punctelor de HIV-1 - In Vitro Whole-Genome Analysis Identifies A Susceptibility Locus For HIV-1 - articole medicale engleza - startsanatate