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Mouse Model Shows The Role Of Cell Signalling In Growth Of Cervical Cancer
Cervical cancer is one of the most prevalent cancers in women worldwide and is the leading cause of cancer death for women in developing countries. In
research published in this week's PLoS Medicine, Douglas Hanahan (University of California San Francisco, USA) and colleagues investigate how cell
signalling in the stroma - the tissue that surrounds a tumour - plays a role in the progression of cervical cancer. Using a mouse model of
cervical cancer, the researchers looked at a protein that is made by the tumor cells known as platelet-derived growth factor (PDGF). The research
finds that the signaling in the stromal cells triggered by the release of this protein stimulates the growth of the tumor.
In a separate perspective article, Rakesh Jain (Harvard Medical School, USA) and colleagues, who were not involved in the study, suggest that the
results offer a "foundation for development of new approaches to the treatment of cervical cancer" that target PDGF signaling to slow the
progression of the disease.
Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
Pietras K, Pahler J, Bergers G, Hanahan D
PLoS Med 5(1): e19.
Click here to view article online
About PLoS Medicine
PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of
human health and disease, together with commentary and analysis of important global health issues.
PLoS Medicine
About the Public Library of Science
The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical
literature a freely available public resource.
Public Library of Science
Mouse Model aratã Rolul Cell semnalizare În creºtere a cancerului de col uterin - Mouse Model Shows The Role Of Cell Signalling In Growth Of Cervical Cancer - articole medicale engleza - startsanatate