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N30 Pharma Announces Successful Initiation Of Human Studies With N30-201
N30 Pharma (N30), a
biopharmaceutical company focused on the discovery, development, and
commercialization of respiratory drugs that target endogenous
s-nitrosothiols, announced that it has successfully completed Phase 1
study of N30-201 in healthy volunteers. N30 intends to develop N30-201 for
the treatment of reactive and obstructive airway diseases, including Cystic
Fibrosis and asthma.
"We are pleased to have begun and completed the first set of human
studies of N30-201. We believe that N30-201 could be an important therapy
for the treatment of many respiratory diseases. Determining the safety of
acute administration of N30-201 to human subjects is the first step,"
commented Charles Scoggin, M.D., Chairman of N30 Pharma.
The primary endpoint of the study was patient safety and
characterization of adverse events, but the company collected
pharmacokinetic and pharmacodynamic data of ascending doses of N30-201.
About N30-201
N30-201 is a proprietary nebulized formulation of s-nitrosoglutathione
(GSNO), an endogenous bronchodilatory molecule that serves as a crucial
store of nitric oxide (NO) bioactivity in the human airway.
About N30 Pharma
N30 Pharma is developing s-nitrosothiol therapies for important unmet
needs in respiratory diseases. N30's strategy focuses on administration of
GSNO to the human airway, and development of small molecule inhibitors of
GSNO reductase. GSNO reductase is the key enzyme in the body that breaks
down GSNO. These approaches allow N30 to deliver long lasting,
physiologically relevant doses of s-nitrosothiols to target systems.
S-nitrosothiols are endogenous molecules that store and transduce nitric
oxide, and are critical modulators of airway and vascular smooth muscle
tone. N30 is a privately held company headquartered in Boulder, Colorado.
N30 Pharma
http://www.n30pharma.com
N30 Pharma anunta de succes iniþierea Omului studii cu N30-201 - N30 Pharma Announces Successful Initiation Of Human Studies With N30-201 - articole medicale engleza - startsanatate