New Insight Into Cell Division
Cells can divide only when certain key proteins are activated and others inhibited. A protein called NIPA and a set of two proteins called cyclin B1 and Cdk1 are some of these key proteins. Until now, scientists had shown that the cyclin B1/Cdk1 complex is needed to initiate and maintain cell division but is destroyed before and after this process. Also, NIPA was shown to regulate the abundance of cyclin B1/Cdk1 before cell division.
Justus Duyster, Florian Bassermann, and their colleagues revealed that cyclin B1/Cdk1 also regulates NIPA during cell division, which indicates that both proteins regulate each other. The scientists suggest that NIPA is inhibited twice: directly before cell division, to activate cyclin B1/Cdk1, and at the beginning of cell division, when NIPA is further inhibited by cyclin B1/Cdk1. At the end of cell division, cyclin B1/Cdk1 is destroyed and NIPA becomes active again.
Article: "Multisite phosphorylation of Nuclear Interaction Partner of ALK (NIPA) at G2/M Involves Cyclin B1/Cdk1" by Florian Bassermann, Christine von Klitzing, Anna Lena Illert, Silvia Muench, Stephan W. Morris, Michele Pagano, Christian Peschel, and Justus Duyster
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Article adapted by Start Sanatate from original press release.
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Noua carte de vizita a divizie de celule - New Insight Into Cell Division - articole medicale engleza - startsanatate