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New Insights Into Novel Mechanisms Of Action Of Genmab's HuMax-EGFr
Genmab A/S 
(CSE: GEN) announced today new insights into the novel mechanisms of action  
of its antibody HuMax-EGFr(TM) (zalutumumab). By using Protein 
Tomography(TM), a relatively new technology which uses an electron 
microscope to view the three dimensional structure of proteins on the 
surface of cells, HuMax-EGFr was shown to lock the EGF receptor in an 
inactive conformation which prevents receptor activation and the binding of 
growth factors. Furthermore, HuMax- EGFr was shown to inhibit EGF receptor 
signaling by preventing receptor dimerization, the pairing of two receptor 
molecules which starts the signaling cascade. All of these mechanisms have 
the potential to interfere with cancer cell growth.
  
"Coupled with previous findings that HuMax-EGFr is able to induce 
potent ADCC and block growth factor binding to EGF receptors, these studies  
have given us greater insight into the novel way HuMax-EGFr works," said 
Lisa N. Drakeman, Ph.D., Chief Executive Officer of Genmab.
  
    
These data will be presented by Genmab and Sidec Technologies AB, at 
the 3rd Novel Solution Seminar for Drug Creation and Development in Tokyo,  
Japan on March 12 and in Osaka, Japan on March 14, 2007.
 
    
About Genmab A/S
    
Genmab A/S is a biotechnology company that creates and develops human 
antibodies for the treatment of life-threatening and debilitating diseases. 
Genmab has numerous products in development to treat cancer, infectious 
disease, rheumatoid arthritis and other inflammatory conditions, and 
intends to continue assembling a broad portfolio of new therapeutic 
products. At present, Genmab has multiple partnerships to gain access to 
disease targets and develop novel human antibodies including agreements 
with Roche and Amgen. A broad alliance provides Genmab with access to 
Medarex, Inc.'s array of proprietary technologies, including the UltiMAb(R) 
platform for the rapid creation and development of human antibodies to 
virtually any disease target. In addition, Genmab has developed 
UniBody(TM), a new proprietary technology that creates a stable, smaller 
antibody format. Genmab has operations in Europe and the US. For more 
information about Genmab, visit http://www.genmab.com.
 
 
    
This press release contains forward looking statements. The words 
"believe", "expect", "anticipate", "intend" and "plan" and similar 
expressions identify forward looking statements. Actual results or 
performance may differ materially from any future results or performance 
expressed or implied by such statements. The important factors that could 
cause our actual results or performance to differ materially include, among 
others, risks associated with product discovery and development, 
uncertainties related to the outcome and conduct of clinical trials 
including unforeseen safety issues, uncertainties related to product 
manufacturing, the lack of market acceptance of our products, our inability 
to manage growth, the competitive environment in relation to our business 
area and markets, our inability to attract and retain suitably qualified 
personnel, the unenforceability or lack of protection of our patents and 
proprietary rights, our relationships with affiliated entities, changes and 
developments in technology which may render our products obsolete, and 
other factors. Genmab is not under an obligation to up-date statements 
regarding the future following the publication of this release; nor to 
confirm such statements in relation to actual results, unless this is 
required by law.
 
    
Genmab(R); the Y-shaped Genmab logo(R); HuMax(R); HuMax-CD4(R); HuMax- 
EGFr(TM); HuMax-Inflam(TM); HuMax-CD20(TM); HuMax-TAC(TM); HuMax-HepC(TM),  
HuMax-CD38(TM); HuMax-ZP3(TM); and UniBody(TM) are all trademarks of Genmab 
A/S.
 
    
UltiMAb(R) is a trademark of Medarex, Inc.
 
Genmab
http://www.genmab.com
		
Noile descoperiri în roman mecanisme de acþiune al Genmab lui HuMax-RFCE - New Insights Into Novel Mechanisms Of Action Of Genmab's HuMax-EGFr - articole medicale engleza - startsanatate