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Nutritional supplement reduces need for traditional ulcerative colitis treatment
According to a study published in the American Gastroenterological Association (AGA) journal Clinical Gastroenterology
and Hepatology, a nutritionally complete oral supplement enriched with fish oil, soluble fiber and antioxidants reduces
reliance on traditional therapies for people with ulcerative colitis. Moreover, people who took the oral supplement were less
likely to start corticosteroid drug therapy, which has many long-term side effects.
"Our study proves that an oral supplement which combines fish oil, soluble fiber and antioxidants is safer and causes fewer
side effects than many of the medications currently available to treat ulcerative colitis," said Douglas Seidner, MD, lead
study author with The Cleveland Clinic. "This supplement will provide yet another treatment option to alleviate symptoms for
patients suffering from this debilitating disease."
Researchers at The Cleveland Clinic conducted a randomized controlled clinical trial of patients 18 and older with mild to
moderate active ulcerative colitis to assess the benefits of adding this oral supplement to standard medical therapy for the
disease. This study shows that patients on corticosteroid therapy who were given the oral supplement vs. a placebo had a
significant reduction in the dose of corticosteroids needed to control clinical symptoms of ulcerative colitis.
Ulcerative colitis is an inflammatory bowel disease in which the lining of the large intestine becomes inflamed and
ulcerated, and most commonly affects people between 15 and 40 years of age. Ulcerative colitis can be attributed to an immune
disorder or heredity, among other things, and is characterized by abdominal cramps, bloody diarrhea and fever.
Treatments for the disease, including corticosteroids and mesalamine are intended to control inflammation. While
corticosteroids are highly effective in the treatment of ulcerative colitis, prolonged use often leads to insomnia, mood
alterations, increased appetite, hypertension, osteoporosis and other adverse events.
Adverse effects of corticosteroid use are a concern to physicians and lead to discontinuation of the therapy by many
patients. However, more than 25 percent of patients who discontinue the therapy have a relapse of symptoms. Previous smaller
studies have shown that fish oil is effective in reducing the need for corticosteroids in ulcerative colitis patients. The
current study combines fish oil with soluble fiber to diminish the inflammation associated with ulcerative colitis symptoms
and positively affect nutrition.
"The need to find new treatments that are safe, effective and inexpensive remains and physicians should consider adding this
combination of active ingredients as an adjuvant therapy for ulcerative colitis," said Seidner.
More information about ulcerative colitis is available at http://www.gastro.org.
About the Study
Researchers at The Cleveland Clinic conducted a randomized controlled study on adult patients over the age of 18 who had
ulcerative colitis for at least six months, had active inflammation according to endoscopic exam results and had symptoms of
mild to moderate activity of the disease. During the study, patients were either given a ready-to-feed carbohydrate-based
drink as a placebo or the Ulcerative Colitis Nutritional Supplement (UCNS) which contains fish oil, soluble fiber and a
combination of vitamins and antioxidants. The UCNS was found to reduce reliance on traditional corticosteroid therapy for
ulcerative colitis in the study population. The oral supplement is manufactured by Ross Products and Abbott Laboratories and
is currently being evaluated for commercial introduction.
About the AGA
The American Gastroenterological Association (AGA) is dedicated to the mission of advancing the science and practice of
gastroenterology. Founded in 1897, the AGA is the oldest medical-specialty society in the United States. The AGA's 14,000
members include physicians and scientists who research, diagnose and treat disorders of the gastrointestinal tract and liver.
On a monthly basis, the AGA publishes two highly respected journals, Gastroenterology and Clinical Gastroenterology and
Hepatology. The AGA's annual meeting is Digestive Disease Week, which is held each May and is the largest international
gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and
gastrointestinal surgery.
About Clinical Gastroenterology and Hepatology
The mission of Clinical Gastroenterology and Hepatology is to provide readers with a broad spectrum of themes in clinical
gastroenterology and hepatology. This monthly peer-reviewed journal includes original articles as well as scholarly reviews,
with the goal that all articles published will be immediately relevant to the practice of gastroenterology and hepatology.
For more information, visit www.cghjournal.org.
Contact: Kimberly Wise
media@gastro.org
301-941-2620
American Gastroenterological Association
http://www.gastro.org
Supliment nutriþional reduce necesitatea de a tradiþionale ulcerative colita tratament - Nutritional supplement reduces need for traditional ulcerative colitis treatment - articole medicale engleza - startsanatate