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OREXIGEN(TM) Therapeutics Announces Issuance Of Broad Patents Covering Composition Of Its Lead Anti-Obesity Compounds
OREXIGEN(TM) Therapeutics, Inc., a
privately held clinical-stage neuroscience company developing novel
strategic approaches to the treatment of obesity, today announced that the
United States Patent and Trademark Office (USPTO) has issued a patent
covering the composition of OREXIGEN'S Excalia(TM), now in a phase IIb
clinical trial for the treatment of obesity. The invention underlying this
patent was made by Dr. Kishore Gadde at Duke University and covers the use
of various combinations of weight-loss promoting anticonvulsants with
compounds that enhance the activity of norepinephrine or dopamine. This
includes the ingredients combined to make Excalia -- zonisamide, an
anticonvulsant, in combination with bupropion, a norepinephrine and
dopamine reuptake inhibitor. U.S. Patent No. 7,109,198 B2 was awarded to
Duke University and is exclusively licensed by OREXIGEN.
The new patent complements a previous patent that similarly covers the
composition of OREXIGEN's Contrave(TM), also an anti-obesity combination
now in an open-label extension of a phase II/III clinical trial. Contrave
is a formulation of bupropion and naltrexone, and U.S. Patent No. 5,817,665
covers various combinations of anti-depressants (e.g. bupropion) with
opioid antagonists (e.g. naltrexone). This composition patent covers any
use of such combinations and is not limited to weight loss. The patent,
awarded to Dr. Lee Dante, is also licensed exclusively to OREXIGEN.
In awarding these patents the USPTO recognized combinations of broad
categories of existing pharmaceuticals as new, protected entities that act
together to produce a novel effect. Additional patent filings from OREXIGEN
are pending.
ABOUT OREXIGEN THERAPEUTICS
OREXIGEN(TM) Therapeutics, Inc. is a privately-held clinical-stage
neuroscience company in San Diego, California developing novel strategic
approaches to the treatment of obesity. OREXIGEN leverages its proprietary
science to design and screen drugs and drug combinations that work together
in the central nervous system to enhance satiety, diminish appetite,
improve energy expenditure and minimize the body's efforts to compensate
for weight loss. OREXIGEN has two lead drug candidates in clinical trials,
Contrave(TM) (phase II/III) and Excalia(TM) (phase IIb), along with a
pipeline of earlier stage drug combinations now being tested. Each is
designed to act on a specific group of neurons in the central nervous
system with the goal of achieving appetite suppression and sustained weight
loss. By targeting different groups of neurons OREXIGEN is working to
develop compounds that each can achieve a different weight loss profile,
providing rapid weight loss where required (Excalia(TM)) or emphasizing
steady, sustainable weight loss where preferred (Contrave(TM)). Further
information about the company can be found at http://www.orexigen.com.
OREXIGEN cautions you that statements included in this press release
that are not a description of historical facts are forward-looking
statements. These forward-looking statements include statements regarding
the scope of patent protection for OREXIGEN's product candidates, the
efficacy and safety of OREXIGEN's product candidates and the potential to
obtain regulatory approval for, and effectively treat obesity with, any of
these product candidates. The inclusion of forward-looking statements
should not be regarded as a representation by OREXIGEN that any of its
plans will be achieved. Actual results may differ materially from those set
forth in this release due to the risks and uncertainties inherent in
OREXIGEN's business, including, without limitation: the scope and validity
of patent protection for OREXIGEN's product candidates; the progress and
timing of OREXIGEN's clinical trials, and the potential for OREXIGEN's
product candidates to receive regulatory approval on a timely basis or at
all; the market potential for obesity, and OREXIGEN's ability to compete in
the obesity market. You are cautioned not to place undue reliance on these
forward-looking statements, which speak only as of the date hereof. All
forward-looking statements are qualified in their entirety by this
cautionary statement and OREXIGEN undertakes no obligation to revise or
update this news release to reflect events or circumstances after the date
hereof.
OREXIGEN Therapeutics, Inc.
http://www.orexigen.com
View drug information on Naltrexone Hydrochloride Tablets.
OREXIGEN (tm) therapeutics anunþã eliberarea a largã de brevete care acoperã compoziþiei sale de lider de compuºi anti-obezitate - OREXIGEN(TM) Therapeutics Announces Issuance Of Broad Patents Covering Composition Of Its Lead Anti-Obesity Compounds - articole medicale engleza - startsanatate