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Over 30 New Studies Of Oral Xeloda(R) Featured At The 2008 Gastrointestinal Cancers Symposium
Roche announced that a
total of 33 abstracts involving its oral chemotherapy Xeloda(R) have been
accepted for presentation at the 2008 Gastrointestinal Cancers Symposium in
Orlando, Fla., from Jan. 25 to 27.
Five poster presentations based on U.S. data offer additional knowledge
about Xeloda. Two of these U.S. abstracts compare the safety profile and
usage patterns of therapy with oral Xeloda to that of intravenous
fluorouracil (5-FU) therapy in gastroesophageal cancer. A second pair of
U.S. abstracts evaluates the usage patterns and cost of Xeloda-based
regimens against those of 5-FU-based regimens in colon and rectal cancer.
The fifth U.S. abstract highlights preclinical efficacy and tolerability
results of a novel Xeloda regimen (7/7, or 7 days on, 7 days off) using
higher daily doses for the treatment of colorectal cancer.
-- Jan. 25, noon to 1 p.m., [Poster No. 72], A claims database analysis of
capecitabine treatment patterns in patients with gastroesophageal
cancer (GEC) (Presenter: Wasif Saif)
-- Jan. 25, noon to 1 p.m., [Poster No. 71], Capecitabine in patients with
gastroesophageal cancer (GEC): A claims database analysis of adverse
events (AEs) (Presenter: Wasif Saif)
-- Jan. 26, 5:30 to 6:30 p.m., [Poster No. 364], A claims database cost-
comparison analysis of capecitabine in the treatment of patients with
colon or rectal cancer (CRC) (Presenter: Edward Chu)
-- Jan. 27, 7 to 8 a.m., [Poster No. 465], Capecitabine use in patients
with colon and rectal cancer (CRC): A claims database analysis of
treatment (Presenter: Edward Chu)
-- Jan. 27, 7 to 8 a.m., [Poster No. A29], In vivo activity of traditional
vs. novel regimens of capecitabine (C) alone and in combination in a
colorectal cancer xenograft model (Presenter: Kenneth Kolinsky)
Collectively, the findings of these studies highlight the efficacy and
safety of oral Xeloda as a potential alternative to 5-FU in
gastroesophageal and colorectal cancers and support further clinical
testing to examine the efficacy and safety benefits of the 7/7 Xeloda
dosing regimen. Global data presentations, including a meta-analysis that
compares the overall survival benefit between Xeloda and 5-FU in adjuvant
and metastatic settings, provide similar insights.
About Xeloda
Xeloda is the only FDA-approved oral chemotherapy for both metastatic
breast cancer and adjuvant and metastatic colorectal cancer. Inactive in
pill form, Xeloda is enzymatically activated within the body; when it comes
into contact with a naturally occurring protein called thymidine
phosphorylase, or TP, Xeloda is transformed into 5-FU, a cytotoxic
(cell-killing) drug. Because many cancers have higher levels of TP than
does normal tissue, more 5-FU is delivered to the tumor than to other
tissue.
A clinically important drug interaction between Xeloda and warfarin has
been demonstrated; altered coagulation parameters and/or bleeding and death
have been reported. Clinically significant increases in prothrombin time
(PT) and INR have been observed within days to months after starting
Xeloda, and infrequently within one month of stopping Xeloda. For patients
receiving both drugs concomitantly, frequent monitoring of INR or PT is
recommended. Age greater than 60 and a diagnosis of cancer independently
predispose patients to an increased risk of coagulopathy.
Xeloda is contraindicated in patients who have a known hypersensitivity
to 5-fluorouracil, and in patients with known dihydropyrimidine
dehydrogenase (DPD) deficiency. Xeloda is contraindicated in patients with
severe renal impairment. For patients with moderate renal impairment, dose
reduction is required.
The most common adverse events (greater than or equal to 20%) of Xeloda
monotherapy were diarrhea, nausea, stomatitis and hand-foot syndrome. As
with any cancer therapy, there is a risk of side effects, and these are
usually manageable and reversible with dose modification or interruption.
About Roche
Hoffmann-La Roche Inc. (Roche), based in Nutley, N.J., is the U.S.
pharmaceuticals headquarters of the Roche Group, one of the world's leading
research-oriented healthcare groups with core businesses in pharmaceuticals
and diagnostics. For more than 100 years in the U.S., Roche has been
committed to developing innovative products and services that address
prevention, diagnosis and treatment of diseases, thus enhancing people's
health and quality of life. An employer of choice, in 2007 Roche was named
Top Company of the Year by Med Ad News, one of the Top 20 Employers
(Science) and ranked the No. 1 Company to Sell For (Selling Power). In
previous years, Roche has been named as a Top Company for Older Workers
(AARP) and one of the Best Companies to Work For in America (Fortune). For
additional information about the U.S. pharmaceuticals business, visit our
websites: http://www.rocheusa.com or http://www.roche.us.
All trademarks used or mentioned in this release are protected by law.
Roche
http://www.rocheusa.com
View drug information on Warfarin Sodium tablets; Xeloda.
Peste 30 de noi studii de Xeloda oralã (R) Prezentat la Simpozionul de cancer gastro-2008 - Over 30 New Studies Of Oral Xeloda(R) Featured At The 2008 Gastrointestinal Cancers Symposium - articole medicale engleza - startsanatate