Panic Disorder, Clinical Model For Testing Whether Mental Stress Can Lead To Cardiovascular Disease
Research at The Baker Heart Research Institute in Melbourne has shown that during panic attacks there are large sympathetic nerve fibre bursts, recorded with sympathetic nerve recording (microneurography) , and increases in noradrenaline release from from sympathetic nerves in the heart. There appear to be also accompanying surges of adrenal medullary epinephrine secretion.
The research team, headed by Professor of Cardiology, Dr Murray Esler, have concluded that potential neural mechanisms of cardiac risk are sympathetic activation during panic attacks (and specifically neuropeptide Y, NPY, release in the heart, perhaps contributing to coronary artery spasm) , release of adrenaline as a co-transmitter in the cardiac sympathetic nerves, impaired noradrenaline neuronal reuptake (augmenting the sympathoneural response to anxiety) and a newly discovered altered pattern of sympathetic single nerve firing (increased probability of multiple nerve firings per heart beat) .
Psychological measures of Anxiety Sensitivity are significantly associated with this phenomena in panic disorder. These findings have now formed the basis for investigations examining the possibility of an epigenetic predisposition to panic disorder.
Changes in the norephinephrine transporter (NET) gene promoter region, taking the form of hypermethylation in the NET gene promoter region appear to support this position and offer an elegant link to the observed effects of impaired noradrenaline reuptake in the heart.
Currently, the research team is examining the impact established treatment modalities can have in these mechanisms. Consequently, people in Victoria who are interested in taking part in research where cognitive behaviour therapy and medication therapy are offered ought to contact the research team on: david.barton@MH.org.au. or 03 9342 8946.
Volunteers ought to not to be receiving treatment from elsewhere nor should they have any of the following conditions: diabetes, heart disease, medicated high blood pressure or another mental illness.
Research team:
Professor Murray Esler
Dr Marlies Alvarenga
Dr David Barton
Dr Elisabeth Lambert
Ms Celia Brenchley
Ms Tye Dawood
Dr Deepak Haikerwal
Dr Assam El-Osta
Dr Ling Guo
Dr Gavin Lambert
Cardiovascular Neurosciences Division
Baker Heart Research Institute
75 Commercial Rd
Prahran Victoria 3004
Australia
http://www.med.monash.edu.au
Tulburare Panic, model clinice pentru testarea dacã stres mental poate duce la boli cardiovasculare - Panic Disorder, Clinical Model For Testing Whether Mental Stress Can Lead To Cardiovascular Disease - articole medicale engleza - startsanatate