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Researchers Discover Gene Mutation Thought To Control Energy Levels
University of Ottawa medical researchers have discovered a mutation in a
gene that is widely considered to be the major controller of energy levels
in
our bodies. The discovery has significant implications for people
suffering from diabetes and for endurance athletes.
This study focused on the gene for AMPK (adenosine monophosphate-activated
protein kinase), which controls the amount of energy in our cells by
becoming active when fuel stores start to deplete, such as during
exercise. The mutation discovered in individuals from two unrelated
families caused
a doubling of AMPK activity in muscle during rest, mimicking a state of
exercise.
The uOttawa research team led by Drs Mary-Ellen Harper, Robert Dent and
Ruth McPherson, in collaboration with researchers in Berkeley California,
also
found that the mutation produces a decrease in the storage in muscle of
fat and an increase in muscle glycogen. The discovery has implications for
the
treatment of type 2 diabetes, as high levels of fat stored in the muscle
have been linked to insulin resistance. In addition, as metformin, a drug
commonly used to both prevent and treat diabetes, acts by increasing AMPK
activity, this discovery provides valuable information for pharmaceutical
research. The findings will also be of great interest to exercise
physiologists, as increased muscle glycogen enhances a person's capacity
for
endurance exercise (e.g., marathon running).
This significant discovery, made possible by grants from the Heart &
Stroke Foundation of Ontario and the generous participation of patients
and
volunteers, is reported in the September 19 issue of the online,
open-access journal, PLoS ONE.
Citation: Costford SR, Kavaslar N, Ahituv N, Chaudhry SN, Schackwitz WS,
et al (2007) Gain-of-Function R225W Mutation in Human AMPKc3 Causing
Increased Glycogen and Decreased Triglyceride in Skeletal Muscle. PLoS ONE
2(9): e903. doi:10.1371/journal.pone.0000903
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PLoS ONE is the first journal of primary research from all areas of
science to employ both pre- and post-publication peer review to maximize
the
impact of every report it publishes. PLoS ONE is published by the Public
Library of Science (PLoS), the open access publisher whose goal is to make
the world's scientific and medical literature a public resource.
http://www.plosone.org
Public Library of Science
Researchers Discover Gene mutaþie cã control Energie Nivele - Researchers Discover Gene Mutation Thought To Control Energy Levels - articole medicale engleza - startsanatate