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Role For Macrophages In Age-related Macular Degeneration

Macrophages--cells involved in the immune response--may have a crucial role in age-related macular degeneration (AMD). Rajendra Apte and colleagues from the Washington University School of Medicine used a mouse model of choroidal neovascularization--new vessel formation, (CNV) --which is an important part of AMD, to show that preventing macrophage entry into the eye encouraged new vessel formation, whereas direct injection of macrophages significantly inhibited this process.

Age-related macular degeneration (AMD) is the leading cause of blindness in people over 50 y of age in at least three continents. CNV is the process by which abnormal blood vessels develop underneath the retina. CNV develops in 10% of patients with AMD but accounts for up to 90% of the blindness from AMD. This study suggests that regulators of macrophages may be a possible therapeutic target in AMD.

Citation: Apte RS, Richter J, Herndon J, Ferguson TA (2006) Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med 3(8): e310.

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Article adapted by Start Sanatate from original press release.
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All works published in PLoS Medicine are open access. Everything is immediately available without cost to anyone, anywhere--to read, download, redistribute, include in databases, and otherwise use--subject only to the condition that the original authorship is properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License.

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030310

CONTACT:

Rajenda Apte
Washington University School of Medicine
Ophthalmology
660 South Euclid Avenue
Box 8096
St.Louis, MO 63110 United States of America
apte@vision.wustl.edu

About PLoS Medicine
PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health issues. For more information, visit http://www.plosmedicine.org/

About the Public Library of Science
The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org/

Contact: Andrew Hyde
Public Library of Science





Rolul Pentru macrofagelor În degenerescenþa macularã legatã de vârstã - Role For Macrophages In Age-related Macular Degeneration - articole medicale engleza - startsanatate