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Role Of Cholesterol In Alzheimer's Disease Unclear, Reports The 'Harvard Men's Health Watch'
It sounds simple: The lower
your cholesterol, the better your heart health. But a man's heart and his
head don't always agree. In fact, the relationships among cholesterol
levels, psychological function, and neurologic disorders are complex and
sometimes controversial, reports the March 2007 issue of Harvard Men's
Health Watch.
There are two major forms of dementia: vascular dementia and
Alzheimer's disease. Vascular dementia results when blood vessel damage
deprives the brain of oxygen. Brain cells die as a result, and mental
function suffers. Some studies link high cholesterol levels to an increased
risk of cognitive impairment, but others report the opposite. More research
is needed to sort this out, but even now, investigations of HDL (good)
cholesterol and mental function have consistently reported that high HDL
levels appear to help preserve mental function in older people.
The connection between Alzheimer's disease and cholesterol is even more
complex. Scientists have learned much of the damage of Alzheimer's comes
from deposits of a sticky protein, called beta-amyloid, in vital areas of
the brain. In some studies, high cholesterol levels appear to accelerate
the formation of beta-amyloid plaques. People with the genetic trait that
increases the level of a particular cholesterol transport protein have a
greatly increased risk of late-onset Alzheimer's.
The urgent question is whether cholesterol-lowering drugs, such as
statins, can reduce the risk of Alzheimer's disease. In the most recent
studies, people who took statins did not appear to be at lower risk for the
disease. Additional research is under way. Right now, it is too early for
firm conclusions on the relationships among cholesterol, cognitive
function, and statin therapy.
Harvard Health Publications
http://www.health.harvard.edu/men
Rolul de colesterol în Boala Alzheimer neclare, rapoarte de la "Harvard pentru barbati ceas de sãnãtate" - Role Of Cholesterol In Alzheimer's Disease Unclear, Reports The 'Harvard Men's Health Watch' - articole medicale engleza - startsanatate