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Semafore Granted Nearly One Million Dollars To Study SF1126 In Multiple Myeloma Patients
Semafore Pharmaceuticals, Inc.
today announced receipt of a grant award from the Multiple Myeloma Research
Foundation (MMRF) for a Phase l trial evaluating its Pl3K inhibitor SF1126
in multiple myeloma. This is the second clinical trial grant awarded to
Semafore-last week the company announced receipt of a grant from Cancer
Treatment Research Foundation (CTRF) to help fund a Phase l trial of SF1126
in solid cancers. Both Phase l trials are expected to commence in 2007.
Separately, Semafore announced that multiple myeloma preclinical studies
sponsored by the company and its collaborators at Emory University have
been selected for an oral presentation at the upcoming 48th Annual Meeting
of the American Society of Hematology (ASH.)
"This generous grant from the MMRF will enable us to rapidly initiate a
clinical trial of SF1126 in multiple myeloma," said Dr. Joseph Garlich,
president and chief scientist of Semafore. "The MMRF has an outstanding
track record of funding innovative research that has significantly
increased the treatment options available to myeloma patients. The PI3
kinase pathway plays a key role in the signaling processes that are vital
to cancer cell proliferation, invasion and metastasis, yet there currently
are no PI3K inhibitors in clinical trials. We are therefore delighted that
both the MMRF and the CTRF have chosen to support cancer trials of our lead
Pl3K inhibitor scheduled to begin in the new year."
The MMRF has awarded Semafore a $996,380 grant to help fund both the
drug manufacturing and the patient costs of a Phase l trial in relapsed and
refractory multiple myeloma patients. The grant award is from the new MMRF
LEAD program designed to encourage myeloma clinical trials for promising
new drugs being developed by young companies.
MMRF founder and chief executive officer Kathy Giusti noted, "Our
mission is to accelerate the development of promising new drugs for
myeloma, and Semafore's innovative approach that targets the Pl3 kinase
pathway has shown significant promise in preclinical studies. There
currently are no Pl3K inhibitors in clinical trials, so it is fitting that
this promising new approach is one of the first recipients of our new LEAD
clinical awards program."
The MMRF's LEAD program is a multi-year research grant commitment
intended to drive and accelerate the development of innovative and
effective multiple myeloma treatments by funding the development of lead
compounds through the early stage drug development process that could have
a significant impact on existing or future myeloma treatments.
Dr Garlich concluded, "The growing interest in the anti-cancer
potential of our Pl3K approach is also highlighted by the fact that data
from preclinical studies of SF1126 in myeloma were selected for an oral presentation at the upcoming ASH meeting, a noteworthy occurrence for a
preclinical study."
SF1126 Oral Presentation at ASH: "A vascular targeted pan PI-3 kinase
inhibitor, SF1126, with activity against multiple myeloma in vivo"
At the 48th Annual Meeting of the American Society for Hematology in
Orlando, Florida, Dr. Donald L. Durden** will give an oral presentation of
in vitro and in vivo preclinical data on SF1126 in multiple myeloma.
Semafore has collaborated with Emory University to conduct these studies,
with the financial support of the Multiple Myeloma Research Consortium
(MMRC). The presentation is abstract # 244 scheduled for December 11, 2006
at 8:15 am EST in Chapin Theater (Level III).
Authors of the study include Pradip De, Qiong Peng, Nandini Dey,
Breanne McDermitt, Sagar Lonial and Donald L. Durden from Emory University,
and Xiaodong Peng and Joseph Garlich from Semafore Pharmaceuticals.
Professor of pediatric oncology and hematology at Emory University
School of Medicine, scientific director of basic and translational research
at the AFLAC Institute for Cancer and Blood Disorders, and chairman of
Semafore's Scientific Advisory Board.
About Multiple Myeloma
Multiple myeloma is an incurable cancer of the blood plasma cell. The
availability of a number of new drugs to treat myeloma is thought to be
extending the lives of many patients, but the historical five-year survival
rate for myeloma patients is only 32 percent. Approximately 50,000 people
in the United States are living with multiple myeloma and an estimated
16,000 new cases are diagnosed each year. Although the peak age of onset of
multiple myeloma is 65 to 70 years of age, recent statistics suggest that
incidence is increasing and is also occurring at an earlier age.
About the Multiple Myeloma Research Foundation
The Multiple Myeloma Research Foundation (MMRF) was established in 1998
as a 501(c)3 non-profit organization by twin sisters Karen Andrews and
Kathy Giusti, a newly diagnosed multiple myeloma patient, with the unique
mission of accelerating the search for a cure for multiple myeloma. Today,
the MMRF is the largest non-profit foundation dedicated to the single
mission of accelerating the search for a cure for multiple myeloma. As the
world's number one funder of myeloma research, the MMRF has raised more
than $70 million to fund more than 200 research grants at more than 70
research institutions around the globe. Currently, the MMRF is funding more
than 30 new compounds and approaches -- in pre-clinical testing and Phase
I, II and III clinical trials -- that show promise in treating patients at
all stages of the disease. For more information about the MMRF, please
visit http://www.multiplemyeloma.org.
About SF1126
SF1126 is a small molecule that selectively inhibits PI3K Class IA
isoforms and other key members of the PI3K pathway such as DNA-PK and mTOR.
Recent advances indicate that these targets play a critical role in the
progression of cancer and many groups are searching for effective safe
inhibitors of these targets. In preclinical studies, SF1126 has been shown
to be a key regulator of many of the processes involved in tumor growth and
dissemination. Preclinically, SF1126 inhibits angiogenesis, induces
apoptosis, controls upstream and downstream signaling and produces
synergistic anti-tumor effects in combination with chemotherapy and
radiation. SF1126 has demonstrated promising activity in a variety of
preclinical cancer models, including prostate, breast, lung, leukemia,
multiple myeloma, brain and other cancers.
About Semafore
Semafore is an Indianapolis-based drug discovery and development
company focused on small molecule modulators of the PI3 kinase (PI3K) and
PTEN cell signaling pathway, one of the most promising target pathways for
multiple disorders, including the company's focus, cancer. Semafore is one
of the first biopharmaceutical companies to focus on both PI3K and PTEN and
has successfully discovered and is developing a portfolio of drug
candidates. The company expects to file an IND for its lead clinical
candidate, PI3K inhibitor SF1126, in December of 2006. Semafore has also
discovered the first drug-like small molecule PTEN modulators for cancer
therapy, cell protection and therapeutic angiogenesis. For more information
see the company's website at http://www.semaforepharma.com.
Semafore Pharmaceuticals
http://www.semaforepharma.com
Semafore acordate de aproape un milion de dolari pentru a studia în SF1126 mielom multiplu de pacienþi - Semafore Granted Nearly One Million Dollars To Study SF1126 In Multiple Myeloma Patients - articole medicale engleza - startsanatate