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Senesco Technologies Reports On Results Of Preclinical Multiple Myeloma Studies
Senesco
Technologies, Inc. ("Senesco" or the "Company") (Amex: SNT) announced
the results of preclinical animal studies focused on multiple myeloma that
were conducted concurrently at Mayo Clinic and the University of Waterloo.
The goal of these studies, which utilized two different dosing regimens,
was to further test the ability of Senesco's Factor 5A technology to induce
apoptosis in tumors. Additionally, the studies evaluated the efficacy of
nanoparticles as a vehicle for encapsulation and delivery of Factor 5A to
tumors.
SCID (severe combined immunodeficiency) mice were injected
subcutaneously with human multiple myeloma cancer cells to form myeloma
tumors in their flanks. Treated mice were injected intratumorally with
Factor 5A therapy encapsulated in nanoparticles, while control mice
received a nanoparticle without the Factor 5A therapy. One of the dosing
regimens showed evidence of significant tumor regression relative to the
untreated control mice, while the other showed a diminished rate of tumor
growth along with some regression.
The Company believes that the results of this study, together with the
results of previous studies may be sufficient to plan the preclinical
toxicology studies to support an Investigational New Drug Application at
the Food and Drug Administration.
About Senesco Technologies, Inc.
Senesco Technologies, Inc. is a U.S. biotechnology company,
headquartered in New Brunswick, NJ. Senesco has initiated preclinical
research to trigger or delay cell death in mammals (apoptosis) to determine
if the technology is applicable in human medicine. Accelerating apoptosis
may have applications to development of cancer treatments. Delaying
apoptosis may have applications to certain diseases inflammatory and
ischemic diseases. Senesco takes its name from the scientific term for the
aging of plant cells: senescence. Delaying cell breakdown in plants extends
freshness after harvesting, while increasing crop yields, plant size and
resistance to environmental stress. The Company believes that its
technology can be used to develop superior strains of crops without any
modification other than delaying natural plant senescence. Senesco has
partnered with leading-edge companies engaged in agricultural biotechnology
and earns research and development fees for applying its gene- regulating
platform technology to enhance its partners' products.
Certain statements included in this press release are forward-looking
statements within the meaning of the Private Securities Litigation Reform
Act of 1995. Actual results could differ materially from such statements
expressed or implied herein as a result of a variety of factors, including,
but not limited to: the development of the Company's gene technology; the
approval of the Company's patent applications; the successful
implementation of the Company's research and development programs and joint
ventures; the success of the Company's license agreements; the acceptance
by the market of the Company's products; success of the Company's
preliminary studies and preclinical research; competition and the timing of
projects and trends in future operating performance, the Company's ability
to meet its funding milestones under its financing transaction, the
Company's ability to comply with the continued listing standards of the
AMEX, as well as other factors expressed from time to time in the Company's
periodic filings with the Securities and Exchange Commission (the "SEC").
As a result, this press release should be read in conjunction with the
Company's periodic filings with the SEC. The forward-looking statements
contained herein are made only as of the date of this press release, and
the Company undertakes no obligation to publicly update such
forward-looking statements to reflect subsequent events or circumstances.
Senesco Technologies, Inc.
http://www.senesco.com
Senesco tehnologii de rapoarte privind rezultatele studiilor preclinice de mielom multiplu - Senesco Technologies Reports On Results Of Preclinical Multiple Myeloma Studies - articole medicale engleza - startsanatate