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Study Examines Drug Delivery With Liposomes

Several chemotherapy drugs can only be given at certain doses because they're highly toxic to healthy cells, and at those doses, the concentration of the drug that reaches cells in the tumor may be quite low. Scientists have been investigating the use of liposomes, hollow spheres of fat molecules, to deliver chemotherapy drugs directly to tumors. These liposomes melt and release their contents when exposed to heat.

In a new study, Ana M. Ponce and Mark W. Dewhirst, D.V.M., Ph.D., of Duke University Medical Center, and colleagues injected doxorubicin-containing liposomes into rats bearing fibrosarcomas. The researchers monitored the rats continuously using magnetic resonance imaging to watch how the liposomes distributed in the body. They also tracked whether it was most effective to inject the liposomes before, during, or before and during heating of the tumor, which triggers the liposomes to dissolve and release the doxorubicin inside.

Based on their results, the researchers conclude that the drug distribution was most effective when the liposomes were given while the tumor was being heated.

Contact: Becky Levine, Duke University Medical Center News Office

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Article adapted by Start Sanatate from original press release.
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Other highlights in the January 3 JNCI

Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jncicancerspectrum.oxfordjournals.org/.

Contact: Andrea Widener
Journal of the National Cancer Institute





Studiul examineazã de droguri cu livrare Liposomes - Study Examines Drug Delivery With Liposomes - articole medicale engleza - startsanatate