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Three-Year Registry Data From 1,278 Women Shows Long-Term Efficacy For Uterine Fibroid Embolization (UFE)
Three-year data from the largest, multi-center,
prospective voluntary registry on any procedure for benign uterine fibroids showed that
90 percent of the women participating avoided a hysterectomy and of these, 85 percent
had a substantial improvement in symptoms and quality of life. The registry included
three-year data on 1,278 patients from 26 sites who had this minimally invasive
interventional radiology treatment for symptomatic fibroids, showing uterine fibroid
embolization is a durable treatment for fibroids with sustained improvement in quality of
life and symptom relief. Twenty to 40 percent of American women age 35 and older, and
nearly 50 percent of pre-menopausal African American women, have uterine fibroids. Of
the 600,000 hysterectomies performed annually in the United States, one-third of these
are to relieve symptoms caused by fibroids. "This registry data is great news for women.
With uterine fibroid embolization, we could significantly decrease the hysterectomy rate
in the United States" says Scott Goodwin, MD, interventional radiologist and lead author.
Uterine fibroids are benign tumors that can cause prolonged, heavy menstrual bleeding
that can be severe enough to cause anemia or require transfusion, disabling pelvic pain
and pressure, urinary frequency, pain during intercourse, miscarriage, interference with
fertility, and an abnormally large uterus resembling pregnancy. UFE is a minimally
invasive interventional radiology treatment that blocks the blood supply to the fibroid
tumors, causing them to shrink and die, and symptoms to subside.
The FIBROID Registry was designed to follow the "real world" outcomes for uterine
fibroid embolization as it became a mainstream treatment widely available across the
country. The purpose of the Registry was to assess the procedure's effectiveness in
improving fibroid-related symptoms, to determine the durability of those improvements,
and to assess the safety of the procedure in broad practice. The 1,278 women who
completed the three-year follow-up had significant improvement in symptoms and in
quality of life (QOL), moving them into the normal range on this validated survey
instrument. The mean symptom scores before embolization were 58.61, and postprocedure
at three years were 16.54. Mean QOL scores pre-embolization were 46.95 and
at three years were 89.55. Eighty-five percent would recommend the procedure to a
family member or friend. The study also identified subgroups of patients that appeared to
have a greater likelihood of improvement.
This data shows that the long-term clinical outcomes of UFE are consistent when the
procedure is performed in any experienced community or academic interventional
radiology practice. "The Registry's outcomes are important not only because of its size,
but also because of the diversity of sites that participated. These results demonstrate that
uterine fibroid embolization is safe and very effective beyond the academic or specialized
centers." The Registry is one of the few efforts ever undertaken to study the efficacy of a
procedure as it disseminates into broad practice, and this is the first such effort for a
fibroid therapy by any specialty.
"It is important for women to know all of their treatment options in order to make an
informed decision. Interventional radiologists can provide a second opinion and assess
whether UFE is a treatment option. The vast majority of women are eligible for this
treatment," says Goodwin. Interventional radiologists use MRI to delineate the location
of each fibroid, determine if a tumor can be embolized, detect alternate causes for the
symptoms, identify pathology that could prevent a women from having UFE, and avoid
ineffective treatments. The number of women requiring retreatment after UFE in the
registry is similar to the surgical reintervention rates, of approximately five percent per
year, following myomectomy.
About Uterine Fibroid Embolization
Uterine fibroid embolization is performed by interventional radiologists, physicians who
are fellowship trained in minimally invasive treatments. Embolization is a common
interventional radiology treatment for benign and cancerous tumors. In uterine fibroid
embolization, the interventional radiologist makes a tiny nick in the skin, about the size
of a pencil tip, and inserts a catheter into the femoral artery. Using real-time imaging, the
physician guides the catheter up the artery and then releases tiny particles, the size of
grains of sand, into the blood vessels feeding the fibroid, cutting off its blood supply,
causing it to shrink and die, and symptoms to subside. Most women return home the next
day and can resume normal activities, with an average full recovery time of seven to 10
days.
About the Society of Interventional Radiology Foundation
The SIR Foundation is a scientific foundation dedicated to fostering research and
education in interventional radiology for the purposes of advancing scientific knowledge,
increasing the number of skilled investigators in interventional radiology, and developing
innovative therapies that lead to improved patient care and quality of life.
Interventional radiologists are physicians who specialize in minimally invasive, targeted
treatments. They offer the most in-depth knowledge of the least invasive treatments
available coupled with diagnostic and clinical experience across all specialties. They use
X-rays, MRI and other imaging to advance a catheter in the body, usually in an artery, to
treat at the source of the disease nonsurgically. As the inventors of angioplasty and the
catheter-delivered stent, which were first used in the legs to treat peripheral arterial
disease, interventional radiologists pioneered minimally invasive modern medicine.
Local interviews, medical illustrations and broadcast quality video footage are
available. More information can be found at http://www.SIRweb.org.
De trei ani in registri datele de la 1278 de femei Afiºeazã pe termen lung eficacitate pentru uterine Fibroid Embolization (UFE) - Three-Year Registry Data From 1,278 Women Shows Long-Term Efficacy For Uterine Fibroid Embolization (UFE) - articole medicale engleza - startsanatate