Tuning Nanostructures For New Drug Delivery Systems
Theses charged peptides represent a new class of biomaterials with excellent potential to solubilize membrane proteins and enzymes, and - as now demonstrated - can also be utilized to stabilize different self-assembled liquid crystalline nanostructures. Moreover, the surface charge density of lipidic nanostructures can be varied in a simple manner. Dr Yaghmur noted, "already the addition of small amounts of designer peptides is sufficient to form systems with excellent potential for various biotechnological applications such as the encapsulation of water-insoluble drugs and the delivery of biological active materials."
In the near future, corresponding colloidal aqueous dispersions with confined inner nanostructures (cubosomes and hexosomes) will offer unique characteristics like high drug load capacities and low viscosity, and here amphiphilic designer peptides may play a key role in improving functionalization and stabilization of theses systems.
Citation:
Yaghmur A, Laggner P, Zhang S, Rappolt M (2007) Tuning Curvature and Stability of Monoolein Bilayers by Designer Lipid-Like Peptide Surfactants.
PLoS ONE 2(5): e479. doi:10.1371/journal.pone.0000479
www.plosone.org/doi/pone.0000479
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Tuning nanostructuri pentru noile sisteme de livrare de droguri - Tuning Nanostructures For New Drug Delivery Systems - articole medicale engleza - startsanatate