'Ancestral Eve' Was Mother Of All Tooth Decay
The team, led by Page Caufield, a professor of cariology and comprehensive care at NYUCD, discovered that Streptoccocus mutans, a bacterium associated with dental caries, has evolved along with its human hosts in a clear line that can be traced back to a single common ancestor who lived in Africa between 100,000 and 200,000 years ago.
S. mutans is transmitted from mothers to infants, and first appears in an infant's mouth at about two years of age. Caufield's findings are reported in an article in the Journal of Bacteriology.
In his analysis of the bacterium, Caufield used DNA fingerprints and other biomarkers that scientists have also employed to trace human evolution back to a single common African ancestor, known as "ancestral Eve."
"As humans migrated around the world and evolved into the different races and ethnicities we know today," Caufield said, "this oral bacterium evolved with them in a simultaneous process called coevolution."
"It is relatively easy to trace the evolution of S. mutans, since it reproduces through simple cell division," says Caufield, who gathered over 600 samples of the bacterium on six continents over the past two decades. His final analysis focused on over 60 strains of S. mutans collected from Chinese and Japanese; Africans; African-Americans and Hispanics in the United States; Caucasians in the United States, Sweden, and Australia; and Amazon Indians in Brazil and Guyana.
"By tracing the DNA lineages of these strains," Caufield said, "We have constructed an evolutionary family tree with its roots in Africa and its main branch extending to Asia. A second branch, extending from Asia back to Europe, traces the migration of a small group of Asians who founded at least one group of modern-day Caucasians."
Additional branches, tracing the coevolution of humans and bacteria from Asia into North and South America, will be drawn in the next phase of Caufield's analysis.
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Article adapted by Start Sanatate from original press release.
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Caufield's coauthors were Deepak Saxena, adjunct associate professor of basic science and craniofacial biology; Yihong Li, associate professor of basic science and craniofacial biology, both at NYU College of Dentistry; and David Fitch, an associate professor in NYU's Department of Biology.
Founded in 1865, New York University College of Dentistry (NYUCD) is the third oldest and the largest dental school in the United States, educating more than 8 percent of all dentists. NYUCD has a significant global reach and provides a level of national and international diversity among its students that is unmatched by any other dental school.
Contact: Christopher James
New York University
"Eva ancestralã" a fost mama tuturor dinte de dezintegrare - 'Ancestral Eve' Was Mother Of All Tooth Decay - articole medicale engleza - startsanatate