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Modified Adenovirus Can Kill Glioma Cells

An enzyme that directs adenovirus function, called hTERT-Ad, can be used to selectively kill malignant brain tumor cells and other cancer cells containing an enzyme called telomerase, by causing the cancer cells to digest themselves and die, according to a new study.

Seiji Kondo, M.D., Ph.D., at the M.D. Anderson Cancer Center in Houston, and colleagues investigated how replicating adenoviruses (CRAds) selectively target and induce death in cancer cells. They infected gliomas, as well as cervical and prostate cancer cells with CRAds regulated by hTERT-Ad. The authors found that hTERT-Ad infected malignant glioma cells or other telomerase-positive cancer cells and caused them to undergo a process of cell death.

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Article adapted by Start Sanatate from original press release.
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Highlights from the May 2006 Journal of the National Cancer Institute

Contact: Laura Sussman, M.D. Anderson Cancer Center

Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jncicancerspectrum.oxfordjournals.org/.

Contact: Ariel Whitworth
Journal of the National Cancer Institute





Modificat Adenovirus poate ucide Glioma Cells - Modified Adenovirus Can Kill Glioma Cells - articole medicale engleza - startsanatate