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AGI Dermatics Data Shows The 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated In Liposomes, Reduces MMP-1 And TNF-alpha In UV Irradiated Skin Cells
AGI Dermatics today
announced new clinical research that the 8-oxo-guanine DNA glycosylase
(OGG1) encapsulated in liposomes enhances DNA repair and reduces MMP-1 and
TNF-alpha in UV irradiated skin cells. The data was presented at the 68th
Annual Meeting of the Society for Investigative Dermatology, May 9 - 12, in
Los Angeles, CA.
"Our clinical study suggests that OGGI liposomes enhance DNA repair in
skin cells," said Daniel Yarosh, PhD, President, AGI Dermatics. "This is
particularly exciting when we consider that existing data shows that 8-oxo-
guanine causes the most significant damage to mitochondrial DNA, which
manifests as nearly all signs of premature aging."
The study examined the question of, if by damaging DNA with reactive
oxygen species (ROS) would there be an increase of either/both matrix
metalloproteinase-1 (MMP-1) and tumor necrosis factor, two factors known to
play roles in photoaging. The formation of 8-oxo-G is induced by ROS from
UVA irradiation, cigarette smoke, environmental stressors, endogenous
enzymatic peroxidation reactions and normal mitochondrial metabolism. Those
mentioned account for nearly all of the symptoms of premature skin aging.
Long-term exposure consequences include photodamage, fine lines and
wrinkles.
Natural cellular repair of the oxidative damage entails complete
removal of 8-oxo-G from DNA via the enzyme OGGI. For the test, OOGI
encapsulated in liposomes showed that the delivery of this enzyme into
fibroblasts increases the rate of repair of 8-oxo-G, and reduces
mitochondrial toxicity and analyzed mRNA content and protein secretion of
MMP-1 and TNF-alpha, with real-time RT- PCR and ELISA.
Normal human dermal fibroblasts (NHDF) were irradiated with solar-
stimulating (ss) UV (UVA340 bulb) to induce MMP-1. Following irradiation,
cells were treated with 1ug/mL OGG1 liposomes for up to 48 hours. The study
then looked at the results of "repair by damaging" the DNA. The treatment
of ssUV stimulated NHEK results in an increased TNF-alpha mRNA expression
after 24 hours and TNF secretion after 48 hours. Both ssUV-induced TNF-
mRNA and secreted protein were reduced by 50% following OGG1 liposome
treatment.
In conclusion, these results indicate that treatment of dermal
fibroblasts and epidermal keratinocytes with OGG1 liposomes enhance DNA
repair, leads to a reduction in the expression and/or secretion of stress
responses proteins such as ssUV-induced MMP-1 and ssUV-induced TNF-a mRNA.
AGI Dermatics is the developer of Remergent, a doctor-dispensed
skincare line based on the science of DNA repair. Remergent DNA Repair
Formula and Antioxidant Refoliator both contain Roxomes, liposomes
encapsulating OGG1, which protect the cells genetic material from ROS.
About AGI Dermatics
AGI Dermatics is the bio-pharmaceutical laboratory that has led
research of DNA repair of the skin for more than 20 years. Founded by
Daniel B. Yarosh, PhD, AGI Dermatics specializes in skin photobiology,
dedicating research and development to DNA repair, solar impact on the
immune system, and cell- signaling in skin. The company's application of
groundbreaking active ingredients and meticulously engineered liposome
delivery systems is validated in controlled clinical studies and published
in dozens of peer-reviewed scientific and medical journals. http://www.agiderm.com.
AGI Dermatics
http://www.agiderm.com
AGI Dermatics date aratã 8-oxo Guanine repararea enzimei de OGG1 încapsulat în Liposomes, reduce MMP-1 ºi TNF-alfa iradiate UV în celulele pielii - AGI Dermatics Data Shows The 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated In Liposomes, Reduces MMP-1 And TNF-alpha In UV Irradiated Skin Cells - articole medicale engleza - startsanatate