ANALIZE MEDICALE DE LABORATOR
Aici gasiti analizele medicale grupate pe categorii precum si detalii generale si specifice pentru categoriile respective.
Selectati o categorie din lista de mai jos:
Solutie antistress!
Construieste poduri :)
Prinde pisica neagra :)
Adult Stem Cells May Improve Treatment Of Certain Cardiovascular Disorders And Autoimmune Diseases
Stem
cells harvested from adult blood or bone marrow may provide benefits
when treating select patients with certain autoimmune diseases and
cardiovascular disorders, according to a clinical review in the
February 27, 008 issue of JAMA.
There are two basic
types of stem cells: embryonic stem cells and adult stem cells. Human
embryonic stem cells are collected from a four to five day old
blastocyst, an early stage in the development of an embryo. These cells
theoretically have the potential to become any type of cell in the
body. Adult stem cells, in contrast, are located in several types of
tissue in different parts of the body, including bone marrow, brain,
mammary glands, testicles, and liver. They usually function as
a
reserve to help replace damaged and aging cells, and are generally
limited in the cell types into which they can differentiate.
The field of stem cell therapy is developing
quickly and has great potential. However, according to the authors,
"but clinical application has lagged due to ethical concerns
or difficulties in harvesting or safely and efficiently expanding
sufficient quantities. In contrast, clinical indications for
blood-derived (from peripheral or umbilical cord blood) and bone
marrow-derived stem cells, which can be easily and safely harvested,
are rapidly increasing."
A review of previous studies related
to clinical indications and outcomes for use of blood and bone marrow
derived cells between January 1997 and December 2007 was performed by
Richard K. Burt,
M.D., of the Northwestern University Feinberg School of Medicine,
Chicago, and colleagues. They combed databases to yield 323 reports
that were analyzed for feasibility and toxicity of treatment. 69
studies were evaluated based on outcomes.
In
preparation for the transplantation of stem cells, a myoablation
regimen is often applied in varying degrees to weaken the immune
system and improve integration of the new cells. When this team
examined studies related to autoimmune diseases, 26 reports
representing 854 patients reported: nonmyeloablative transplants with a
treatment-related mortality rate of less than one percent (2/220
patients); dose-reduced myeloablative transplants with a
treatment-related mortality rate of less than two percent (3/197
patients); and intense myeloablative regiments (including total body
irradiation or high-dose bulsulfan, which is often used in some types
of chronic leukemia) with a mortality rate of 18 percent.
The researchers believe that this is still inconclusive evidence for
this type of study. "While all trials performed during the
inflammatory stage of autoimmune disease suggested that transplantation
of hematopoietic [formation of blood or blood cells] stem cells (HSCs)
may have a potent disease-remitting effect, remission duration remains
unclear, and no randomized trials have been published," they write.
When
reporting on cardiovascular diseases, the researchers examined 17
reports about 1,002 heart attack patients, 16 reports about 493
patients with chronic coronary artery disease, and three meta-analysis.
The data seemed to suggest that stem cell transplantation in
patientswith coronary artery disease could contribute to some
improvement in cardiac function.
The authors conclude with some cautiously hopeful words. "Stem cells
harvested
from blood or marrow, whether administered as purified HSCs or
mesenchymal [cells that develop into connective tissue, blood vessels
and lymphatic tissue] stem cells or as an unmanipulated or unpurified
product can, under appropriate conditions in select patients, provide
disease-ameliorating effects in some autoimmune diseases and
cardiovascular disorders. Clinical trials are needed to determine the
most appropriate cell type, dose, method, timing of delivery, and
adverse effects of adult HSCs for these and other nonmalignant
disorders."
Clinical Applications of Blood-Derived and Marrow-Derived Stem
Cells for Nonmalignant Diseases
Richard
K. Burt, MD; Yvonne Loh, MD; William Pearce, MD; Nirat Beohar, MD;
Walter G. Barr, MD; Robert Craig, MD; Yanting Wen, MD; Jonathan A.
Rapp, MD; John Kessler, MD
JAMA. 2008;299(8):925-936.
Click
Here For Abstract
Written by Anna Sophia McKenney
Copyright: Start Sanatate
Not to be reproduced without permission of Start Sanatate
Adult celule embrionare pot îmbunãtãþi tratamentul anumitor tulburãri cardiovasculare ºi boli autoimune - Adult Stem Cells May Improve Treatment Of Certain Cardiovascular Disorders And Autoimmune Diseases - articole medicale engleza - startsanatate