Amyloid As A Depot For The Formulation Of Long-Acting Drugs
These extraordinary properties make amyloids attractive for applications in nanotechnology. This week in the open-access online journal PLoS Biology, Samir Maji, Jean Rivier, and Roland Riek suggest the use of amyloids in the formulation of long-acting drugs, which are active over extended periods of days and weeks.
Long-acting drugs have been designed to increase patient comfort, convenience, dosage accuracy and assurance of patient compliance for drugs that have a low oral bioavailability.
It is their rationale that amyloids have the properties required of a long-acting drug because they are stable depots that guarantee a controlled release of the active peptide drug from the amyloid termini.
This concept is tested with a family of short- and long-acting analogs of gonadotropin-releasing hormone, and it is shown that amyloids thereof can act as a source for the sustained release of biologically active peptides.
Amyloid as a depot for the formulation of long-acting drugs
Maji SK, Schubert D, Rivier C, Lee S, Rivier JE, et al.
PLoS Biol 6(2): e17. doi:10.1371/journal.pbio.0060017
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Amyloid ca un depou pentru formularea de medicamente cu acþiune de lungã duratã - Amyloid As A Depot For The Formulation Of Long-Acting Drugs - articole medicale engleza - startsanatate