Anti-Malarial Prevents Cancer In Mice
In the study, chloroquine was shown to inhibit the development of Myc-induced lymphomas (a mouse model of Burkitt lymphoma) and to inhibit the development of lymphomas in ATM-deficient mice (a mouse model of ataxia telangiectasia). By contrast, chloroquine did not inhibit the development of lymphomas in p53-deficient mice. Further analysis indicated that chloroquine induced cellular features of autophagy (self-eating) and mediated its effects by inducing lysosomal stress and provoking a p53-dependent cell death. The authors therefore suggested that modulating autophagy, either using chloroquine or other approaches, might provide a new avenue for the development of anticancer therapeutics.
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Article adapted by Start Sanatate from original press release.
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Title: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
Author Contact:
Michael B. Kastan
St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
John L. Cleveland
The Scripps Research Institute, Jupiter, Florida, USA.
Accompanying Commentary Title:
Antimalarial therapy prevents Myc-induced lymphoma
Author Contact:
Chi V. Dang
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Source: Karen Honey
Journal of Clinical Investigation
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