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Asacol 800mg MR Tablets Dosed At 4.8g/Day Herald Fast Symptom Relief And Improved Quality Of Life For Moderately Active UC Patients

Procter & Gamble Pharmaceuticals (NYSE: P&G) announced that Asacol(R) (mesalazine) 800mg Modified Release (MR) tablets are now available in the UK for the treatment of mild to moderate acute exacerbations of ulcerative colitis (UC), and the maintenance of remission in UC and Crohn's ileo-colitis patients.1 The ASCEND I and II clinical trials have shown that Asacol 800mg MR tablets at 4.8 g/day provide symptom relief* 10 days faster (median time) than a mesalazine 400mg at 2.4 g/day for moderate UC patients.2 The new dose also provides a significant improvement in quality of life at three weeks3 (as a mean change from baseline).

"It is difficult to underestimate the emotional distress and disruption caused by the symptoms of acute ulcerative colitis. To have an effective treatment that reduces the time to symptom relief with no significant increase in side effects compared to the current standard dose is a significant clinical advance", said Simon Travis, DPhil, FRCP, Consultant Physician and Gastroenterologist at the John Radcliffe Hospital in Oxford.

The ASCEND I and II clinical trials evaluated overall treatment success as the primary endpoint. In addition, pooled results from these trials demonstrated that for moderately active UC patients receiving Asacol 800mg MR tablets dosed at 4.8 g/day, median time to resolution of both rectal bleeding and stool frequency (symptom relief) was 10 days faster, 19 days compared to 29 days, than for those receiving a mesalazine 400mg at 2.4 g/day (p=0.02).2 Asacol 800mg MR tablets dosed at 4.8 g/day also provided significant improvement in quality of life at three weeks as indicated by the mean change from baseline in total quality of life (IBDQ**) scores at three and six weeks (34 vs. 45 respectively, p





Asacol MR 800mg comprimate administrat doze la 4.8g/Day Herald repede a simptomelor ºi îmbunãtãþirea calitãþii vieþii pentru pacienþi uc activã moderatã - Asacol 800mg MR Tablets Dosed At 4.8g/Day Herald Fast Symptom Relief And Improved Quality Of Life For Moderately Active UC Patients - articole medicale engleza - startsanatate