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Beyond The Abstract - Uroplakin III-Delta4 Messenger RNA As A Promising Marker To Identify Nonulcerative Interstitial Cystitis

BERKELEY, CA (UroToday.com) - Uroplakin III-delta 4, a splice variant of UP III, was isolated by my Japanese colleagues, Dr. T Yoshiki and others, although its protein structure and function still remains unclear. In this study, the up-regulation of UP III-delta 4 gene was specifically found in non-ulcerative type interstitial cystitis (IC). At the time of this first report, specific antibodies against this variant form had not been available. We therefore could not confirm up-regulation of UP III-delta 4 in non-ulcerative type IC at protein level. We are now trying to confirm the findings at protein level. If we could establish new diagnostic system for UP III-delta 4 protein, new knowledge about IC including relationship between ulcerative type and non-ulcerative type IC would be provided

Written by

Yoshiyuki Kakehi, MD, PhD, as part of Beyond the Abstract on UroToday.com. This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations etc... of their research by referencing the published abstract.

Link to full abstract

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Dincolo de abstract - Uroplakin III-Delta4 ARN mesager ca un marker promiþãtoare pentru a identifica Nonulcerative cistitã interstiþialã - Beyond The Abstract - Uroplakin III-Delta4 Messenger RNA As A Promising Marker To Identify Nonulcerative Interstitial Cystitis - articole medicale engleza - startsanatate