BioLineRx Presents Pre-Clinical Data Demonstrating That BL-1021 Is Safe And Effective In Treating Neuropathic Pain
"Based on the promising data presented here, we believe that BL-1021 has the potential to be a safe and effective drug for neuropathic pain, and we look forward to the initiation of the clinical trial program for this compound in 2008," stated Morris C. Laster, MD, chief executive officer of BioLineRx. "During the course of the year, we expect to significantly expand our clinical pipeline to a total of five therapeutic candidates."
BL-1021 is an orally available small molecule for the treatment of neuropathic pain. In pre-clinical trials, BL-1021 showed a significant reduction in symptoms of neuropathic pain with reduced side effects. The molecule was given orally and in all cases was found to be superior to available treatments due to its increased efficacy and minimal side effects. Furthermore, the experiments demonstrated that BL-1021 demonstrated potent analgesia drug without noticeable side effects of sedation and cardiac arrhythmias, which often plague other anti pain compounds.
BL-1021 is being developed by BioLineRx, Ltd. under a worldwide exclusive license from Ramot at Tel Aviv University Ltd. and Bar-Ilan Research and Development Company Ltd., the technology transfer arms of Tel Aviv University and Bar-Ilan University respectively. BL-1020 was discovered by Professor Abraham Nudelman from the Department of Chemistry, Bar-Ilan University; and Ada Rephaeli, Ph.D., Professor Abraham Weizman, MD, and Irit Gil-Ad, Ph.D. from the Sackler Faculty of Medicine, Tel Aviv University.
About Neuropathic Pain
Neuropathic pain is caused by a primary lesion or dysfunction in the nervous system. It is associated with various conditions including shingles and diabetes and affects 15 million people in the US alone.
About BioLineRx
BioLineRx, a clinical stage drug development company traded on the Tel Aviv Stock Exchange (TASE:BLRX), is dedicated to building a robust pipeline of promising therapeutics for unmet medical needs. The Company's leading programs are BL-1020, currently in Phase 2 testing for the treatment of schizophrenia, and BL-1040, about to initiate clinical trials for the treatment of damaged heart tissue post-myocardial infarction. Additional products under development include compounds for the treatment of cancer and CNS, cardiovascular, metabolic, infectious and autoimmune diseases.
BioLineRx advances projects from early stage discovery and lead generation to advanced clinical trials. BioLineRx partners with researchers, universities and biotech companies to further the development of promising compounds. The Company was founded in 2003 by leaders in the Israeli life science arena including Teva Pharmaceuticals Ltd., venture capital firms Giza Venture Capital and Pitango Venture Capital, and Hadasit, the technology transfer company of Hadassah Hospital and the Jerusalem Development Authority. For more information, please visit http://www.biolinerx.com.
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BioLineRx pre-a prezentat date clinice care sã demonstreze cã BL-1021 este sigurã ºi eficace în tratamentul durerii neuropate - BioLineRx Presents Pre-Clinical Data Demonstrating That BL-1021 Is Safe And Effective In Treating Neuropathic Pain - articole medicale engleza - startsanatate