Drug That Mimics 'good' Cholesterol Has Mixed Effect On Coronary Atherosclerosis
The results of a study presented recently at the American College of Cardiology's 56th Annual Scientific Session showed that CSL-111, a drug that mimics HDL, did not significantly reduce plaque in coronary arteries in patients with a recent episode of ACS. However, patients taking the drug showed improvement in two indexes that assess changes in the blood vessels. ACC.07 is the premier cardiovascular medical meeting, bringing together cardiologists to further breakthroughs in cardiovascular medicine. The study will be simultaneously published in the Journal of the American Medical Association (JAMA) and will appear in the March 28 print issue.
The Effect of Reconstituted High-Density Lipoprotein on Atherosclerosis - Safety and Efficacy trial, also known as ERASE, was coordinated by the Montreal Heart Institute with 17 sites throughout Canada. In this randomized, blinded clinical trial, 183 patients suffering an ACS event within the previous two weeks received up to four weekly infusions of placebo (n=60), 40 mg/kg (n=111) or 80 mg/kg (n=12) of CSL-111. The higher dosage of CSL-111 was discontinued early because of liver function test abnormalities. Assessment of coronary arteries was performed using intravenous ultrasound (IVUS) at baseline and at two to three weeks after the study infusions. IVUS is a technique in which a tiny ultrasound probe is inserted into the coronary arteries, providing a precise and reproducible method for determining the change in plaque, or atheroma, during treatment. Quantitative coronary angiography also was used to assess changes in the blood vessels.
A total of 145 patients had evaluable, serial IVUS examinations. The difference in reduction in coronary atheroma volume after four weekly infusions of CSL-111 or placebo (-3.4% versus -1.6% respectively) was not significantly different. However, when compared to baseline, the results for patients infused with CSL-111 were statistically significant (p
De droguri care imitã "bunã" a colesterolului amestecat efect asupra aterosclerozei coronariene - Drug That Mimics 'good' Cholesterol Has Mixed Effect On Coronary Atherosclerosis - articole medicale engleza - startsanatate