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Estrogen affects the male and female brain differently
University of Minnesota researchers have demonstrated for the first time how estrogen affects learning and memory. They
found that estrogen can activate particular glutamate receptors within the hippocampus, the brain region responsible for many
aspects of learning and memory. Glutamate is the primary excitatory neurotransmitter in the brain, allowing for fast
communication between neurons. By examining hippocampal neurons from rats, researchers also observed that estrogen only
activated the processes related to learning and memory in the brains of female rats and not males. While it has been well
documented that estrogen influences other behaviors beyond reproduction, including learning and memory, the mechanism has
remained elusive. The findings of this research are in this week's Journal of Neuroscience.
"We believe this is an important first step in understanding not just how estrogen affects learning and memory, but also a
variety of non-reproductive behaviors," says Paul Mermelstein, Ph.D., assistant professor of neuroscience at the University
of Minnesota and lead researcher. "Estrogen activation of glutamate receptors within other brain regions could also
potentially account for the well-documented actions of this hormone on female motor control and pain sensation."
Marissa Boulware, a University of Minnesota neuroscience graduate student who performed the studies states, "Every day
post-menopausal women face the dilemma of taking estrogens to improve their cognitive abilities, knowing it may pose a
potential heath risk. By better understanding how estrogen acts upon our brain, one day we may develop novel therapies using
non-steroidal drugs to mimic the specific actions of estrogen on processes related to learning and memory, affording the
cognitive benefits of estrogen without any detrimental side effects."
The research was funded by the National Institutes of Health.
Contact: Molly Portz
mportz@umn.edu
612-625-2640
University of Minnesota
http://www.umn.edu
Estrogenii afecteazã bãrbaþi ºi femei, creierul diferit - Estrogen affects the male and female brain differently - articole medicale engleza - startsanatate