ANALIZE MEDICALE DE LABORATOR
Aici gasiti analizele medicale grupate pe categorii precum si detalii generale si specifice pentru categoriile respective.
Selectati o categorie din lista de mai jos:
Solutie antistress!
Construieste poduri :)
Prinde pisica neagra :)
Fruit Fly Gene Enables Oxygen-Deprived Cell Survival
An gene has been identified in fruit flies that can help
oxygen-deprived cells live longer, according to an article released on
October 17, 2008 in the open-access journal PLoS Genetics.
Oxygen-deprivation in cells, called hypoxia, occurs in many critical
situations, including heart attack, stroke, and other neurological and
respiratory conditions. In these situations, cells in vital tissues and
organs may die or be damaged. While many life forms are able to
suppress non-essential activity, to survive the lack of oxygen, but the
mechanism behind this shift was not known.
Scientists often use fruit flies to perform studies because
their cellular mechanisms are similar to humans' cellular processes. To
investigate hypoxia in fruit flies, researchers at the University of
California, San Diego School of Medicine examined a strain that had
developed tolerance to severely oxygen depleted conditions. The flies'
genes were then compared to examined the normal fruit fly Drosophila
melanogaster genome for differences in gene expression.
The researchers narrowed the possibilities to one regulatory gene:
“A transcriptional suppressor, called hairy, is crucial for
reducing the mismatch between supply and demand of oxygen,”
said Dan Zhou, first author on the study. The principal investigator,
Gabriel G. Haddad, expounded on the mechanism used: “We
discovered that the hairy gene binds to and shuts off, or
suppresses, activation of many genes.” He continued:
“When hairy is activated, it puts the brakes on
various signaling pathways in the cell, enabling the cells to become
resistant to the low-oxygen environment.” This
transcriptional "switch" allows the cells to minimize their cellular
processes in a "brown out," saving energy for more critical functions
in the cell. Haddad added: "While there are multiple pathways that
contribute to the ability of this strain of flies to tolerate hypoxia,
our study demonstrates that hairy-mediated metabolic suppression plays
a critical role.”
By gaining a deeper understanding of the Drosphilia cell mechanism, the
scientists hope to help human cells and tissues adapt and survive in
low-oxygen situations.
Mechanisms Underlying Hypoxia Tolerance in Drosophila
melanogaster: hairy as a Metabolic Switch.
Zhou D, Xue J, Lai JCK, Schork NJ, White KP, et al.
PLoS Genet 4(10): e1000221.
doi:10.1371/journal.pgen.1000221
Click
Here For Full Length Article
Anna Sophia McKenney
Copyright: Start Sanatate
Not to be reproduced without permission of Start Sanatate
Fructe Fly Gene Activeazã oxigen-privaþi celulã de supravieþuire - Fruit Fly Gene Enables Oxygen-Deprived Cell Survival - articole medicale engleza - startsanatate