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Genetically Modified Cells Attack Tumors
Neuroblastoma tumors have been
successfully treated in the lab with genetically modified cells that sought
out and activated a chemotherapy drug placed directly at the cancer cells,
according to investigators at St. Jude Children's Research Hospital and
their colleagues at City of Hope National Medical Center (Duarte, CA) and
the University of British Columbia (Vancouver, Canada). Neuroblastoma is a
solid tumor that arises in a part of the nervous system outside the brain.
The researchers showed that the cells migrated to tumors regardless of
how small the tumors were or where they were located in the body. The cells
produced an enzyme that activated the chemotherapy drug CPT-11 (irinotecan)
at the site of the tumors. A report on this work appears in the Dec. 20
issue of the journal PLoS ONE.
The study is the first to demonstrate that such cells, called neural
stem- progenitor cells (NSPCs), can be used to target solid tumors that
have spread. The fact that the drug is already used to treat cancers should
make it easier to translate these laboratory findings to the clinic, the
researchers noted.
Authors include Rebecca A. Bush, Doris A. Phelps, Joanna S. Remack,
Karina Jin Yoon, Philip M. Potter and Mary K. Danks (St. Jude); Karen S.
Aboody, Elizabeth Garcia, Marianne Z. Metz, Joseph Najbauer, Kristin A.
Justus, Shanna Gillespie and Carlotta A. Glackin (City of Hope) and Seung
U. Kim (University of British Columbia).
This work was supported in part by the National Institutes of
Health/National Cancer Institute, Stop Cancer Foundation, Phi Beta Psi
Sorority, Rosalinde and Arthur Gilbert Foundation, Neidorf Family
Foundation, Marcus Foundation and ALSAC.
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital is internationally recognized for
its pioneering work in finding cures and saving children with cancer and
other catastrophic diseases. Founded by late entertainer Danny Thomas and
based in Memphis, Tenn., St. Jude freely shares its discoveries with
scientific and medical communities around the world. No family ever pays
for treatments not covered by insurance, and families without insurance are
never asked to pay. St. Jude is financially supported by ALSAC, its
fund-raising organization. For more information, please visit
http://www.stjude.org/.
St. Jude Children's Research Hospital
http://www.stjude.org/
Modificate genetic, tumorile celulelor atac - Genetically Modified Cells Attack Tumors - articole medicale engleza - startsanatate