ANALIZE MEDICALE DE LABORATOR
Aici gasiti analizele medicale grupate pe categorii precum si detalii generale si specifice pentru categoriile respective.
Selectati o categorie din lista de mai jos:
Solutie antistress!
Construieste poduri :)
Prinde pisica neagra :)
Inflammation-Induced Colon Cancer Stopped In Its Tracks By TNF-Alpha Antagonist
Individuals with the inflammatory bowel disease ulcerative colitis are at increased risk of developing colon cancer. New data generated by Naofumi Mukaida and colleagues at Kanazawa University, Japan, identified a central role for the soluble factor TNF-alpha in the development of colon cancer in mice in which inflammation of the bowel was induced by administration of azoxymethane (AOM) followed by repeated dextran sulfate sodium (DSS) ingestion. Expression of TNF-alpha was increased in the colon of normal mice treated with AOM and DSS and this was followed by the development of tumors in the colon. Mice lacking one of the receptors for TNF-alpha and mice treated with an antagonist of TNF-alpha were markedly protected from the effects of treatment with AOM and DSS, developing less inflammation of the colon and fewer tumors in the colon. As suggested by the authors, and by Ezra Burstein and Eric R. Fearon in an accompanying commentary, these data provide clear rationale for the idea that drugs antagonizing TNF-alpha (such as those used to treat individuals with rheumatoid arthritis) might be useful in reducing the risk of colon cancer in individuals with ulcerative colitis.
----------------------------
Article adapted by Start Sanatate from original press release.
----------------------------
TITLE: Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
AUTHOR CONTACT:
Naofumi Mukaida
Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
ACCOMPANYING COMMENTARY TITLE: Colitis and cancer: a tale of inflammatory cells and their cytokines
AUTHOR CONTACT:
Eric R. Fearon
University of Michigan Medical School, Ann Arbor, Michigan, USA.
Ezra Burstein
University of Michigan Medical School, Ann Arbor, Michigan, USA.
Source: Karen Honey
Journal of Clinical Investigation
Inflamaþia indusã de cancer de colon sa oprit în piste de antagonist de TNF-alfa - Inflammation-Induced Colon Cancer Stopped In Its Tracks By TNF-Alpha Antagonist - articole medicale engleza - startsanatate
