Neuronal nicotinic receptor antibodies and autonomic neuropathy
Several classical neurological disorders involve autoimmune-mediated disruption of peripheral synapses, the best known being myasthenia gravis that is caused by circulating antibodies to the muscle nicotinic receptor.
In this issue, Vernino et al. examine such a disease mechanism in a disorder involving peripheral autonomic ganglia, autoimmune autonomic neuropathy (AAN).
The authors injected mice with IgG from rabbits immunized with an alpha-3 fusion protein to test a requirement for an antibody-mediated disorder: passive transfer.
The recipient mice had impaired cholinergic ganglionic transmission and signs of autonomic failure. Likewise, mice injected with serum from human AAN patients also developed a similar phenotype.
Journal of Neuroscience
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Neuronale receptorului nicotinic anticorpi ºi autonome neuropatie - Neuronal nicotinic receptor antibodies and autonomic neuropathy - articole medicale engleza - startsanatate