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Proof Of Concept Study Explores Probiotic Approach To Treating Gum Disease
A new study
published in the November issue of the Journal of Dental Research shows
that application of beneficial bacteria as an adjunct to traditional
therapy may become a valid, non-antibiotic treatment approach for
periodontitis (gum disease). In this small-scale animal study, researchers
applied a mixture of beneficial bacteria after scaling and root planing
(removal of bacterial plaque from the crown and root of the tooth surface),
a concept called Guided Pocket Recolonization, or GPR. With the emergence
of antibiotic resistance and the lack of non-antibiotic treatment options,
this GPR approach may provide a valuable addition or alternative to
treatment options for periodontitis.
This is the first study to test the concept of bacterial replacement
therapy in the treatment of plaque-related periodontal disease, and
analysis of the data showed, in a beagle dog model, that when beneficial
bacteria were applied in periodontal pockets adjunctively after root
planing, repopulation by bacteria associated with gum disease was delayed
and reduced, as was the degree of inflammation, at a clinically significant
level.
"While this NIDCR-funded investigation provides a proof of concept that
the application of beneficial bacteria may supplement traditional methods
of periodontal therapy, additional studies are needed to determine how this
concept can be applied in the clinical practice of periodontology," said
Wim Teughels, corresponding author and professor in the Department of
Periodontology at Catholic University Leuven. "The principal investigator,
Marc Quirynen, also a professor at Catholic University Leuven, and the
international team behind this project are continuing investigations with a
focus on testing beneficial bacteria that are both helpful and
non-pathogenic to humans. We hope the current study will inspire other
investigators to consider periodontal disease therapy from this novel
perspective."
The Journal of Dental Research (JDR) is the official publication of the
International & American Associations for Dental Research (IADR/AADR), and
continues to hold the top SIF ranking of all dental journals worldwide. The
IADR is a non-profit organization with more than 11,000 individual members
worldwide, dedicated to: (1) advancing research and increasing knowledge to
improve oral health, (2) supporting the oral health research community, and
(3) facilitating the communication and application of research findings for
the improvement of oral health worldwide. The AADR is the largest Division
of the IADR, with more than 4,000 members in the United States.
International Association for Dental Research
http://www.iadr.org
Dovada Concept Studiul analizeaza probiotic abordare sã trateze Gumã de Boli - Proof Of Concept Study Explores Probiotic Approach To Treating Gum Disease - articole medicale engleza - startsanatate