Spatially Resolved Non-invasive Chemical Stimulation For Modulation Of Signaling In Reconstructed Neuronal Networks
Control over the network architecture and alignment of the network with the microfluidic interface is achieved by modification of the chip surface with cell-adhesive substances. The activity patterns of individual neurons in networks are manipulated by localized neurotransmitter application. This approach may be employed for the investigation of the influence of chemical gradients on network formation and signal processing in neuronal networks.
Functional coupling of neuronal cells with silicon-based devices opens perspectives in information technologies and medical engineering.
by Dr Y Mourzina, Mr A Steffen, Mr D Kaliaguine, Dr B Wolfrum, Dr P Shulte, Dr S Böcker-Meffert and Professor A Offenhäusser
Tim Watson
tim.watson@royalsoc.ac.uk
Royal Society
http://www.royalsoc.ac.uk
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Spatial rezolvate non-invaziva modulãrii chimice pentru stimularea de semnalizare reconstruit în reþelele neuronale - Spatially Resolved Non-invasive Chemical Stimulation For Modulation Of Signaling In Reconstructed Neuronal Networks - articole medicale engleza - startsanatate